Genetic influences on prepulse inhibition of startle reflex in humans

Andrey P. Anokhin; Andrew C. Heath; Erin Myers; Angela Ralano; Suzanne Wood

doi:10.1016/j.neulet.2003.09.014

Genetic influences on prepulse inhibition of startle reflex in humans

Andrey P. Anokhin, Andrew C. Heath, Erin Myers, Angela Ralano, Suzanne Wood

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106 Scopus citations

Abstract

Prepulse inhibition (PPI) is a suppression of the startle reflex that occurs when an intense startling stimulus is preceded by a weaker 'prepulse' stimulus. PPI deficits have been implicated in the biological bases of schizophrenia and some other neuropsychiatric disorders and proposed as a possible biological marker (endophenotype) for genetic studies. However, little is known about the genetic determination of PPI in humans. We examined acoustic eye-blink startle reflex and PPI in 142 young female twins (40 monozygotic and 31 dizygotic pairs) and conducted a biometrical genetic analysis using structural equation modeling. PPI showed significant heritability suggesting that over 50% of PPI variance in this sample can be attributed to genetic factors. Baseline startle magnitude showed higher heritability (about 70%).

Original language	English
Pages (from-to)	45-48
Number of pages	4
Journal	Neuroscience Letters
Volume	353
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2003.09.014
State	Published - Dec 15 2003

Keywords

Genetics
Heritability
Prepulse inhibition
Sensorimotor gating
Startle reflex
Twins

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10.1016/j.neulet.2003.09.014

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title = "Genetic influences on prepulse inhibition of startle reflex in humans",

abstract = "Prepulse inhibition (PPI) is a suppression of the startle reflex that occurs when an intense startling stimulus is preceded by a weaker 'prepulse' stimulus. PPI deficits have been implicated in the biological bases of schizophrenia and some other neuropsychiatric disorders and proposed as a possible biological marker (endophenotype) for genetic studies. However, little is known about the genetic determination of PPI in humans. We examined acoustic eye-blink startle reflex and PPI in 142 young female twins (40 monozygotic and 31 dizygotic pairs) and conducted a biometrical genetic analysis using structural equation modeling. PPI showed significant heritability suggesting that over 50% of PPI variance in this sample can be attributed to genetic factors. Baseline startle magnitude showed higher heritability (about 70%).",

keywords = "Genetics, Heritability, Prepulse inhibition, Sensorimotor gating, Startle reflex, Twins",

author = "Anokhin, {Andrey P.} and Heath, {Andrew C.} and Erin Myers and Angela Ralano and Suzanne Wood",

note = "Funding Information: This study was supported by grants DA00421 from the National Institute on Drug Abuse and 5P50 AA11998 from the National Institute on Alcohol Abuse and Alcoholism (Missouri Alcoholism Research Center).",

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AU - Anokhin, Andrey P.

AU - Heath, Andrew C.

AU - Myers, Erin

AU - Ralano, Angela

AU - Wood, Suzanne

N1 - Funding Information: This study was supported by grants DA00421 from the National Institute on Drug Abuse and 5P50 AA11998 from the National Institute on Alcohol Abuse and Alcoholism (Missouri Alcoholism Research Center).

PY - 2003/12/15

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N2 - Prepulse inhibition (PPI) is a suppression of the startle reflex that occurs when an intense startling stimulus is preceded by a weaker 'prepulse' stimulus. PPI deficits have been implicated in the biological bases of schizophrenia and some other neuropsychiatric disorders and proposed as a possible biological marker (endophenotype) for genetic studies. However, little is known about the genetic determination of PPI in humans. We examined acoustic eye-blink startle reflex and PPI in 142 young female twins (40 monozygotic and 31 dizygotic pairs) and conducted a biometrical genetic analysis using structural equation modeling. PPI showed significant heritability suggesting that over 50% of PPI variance in this sample can be attributed to genetic factors. Baseline startle magnitude showed higher heritability (about 70%).

AB - Prepulse inhibition (PPI) is a suppression of the startle reflex that occurs when an intense startling stimulus is preceded by a weaker 'prepulse' stimulus. PPI deficits have been implicated in the biological bases of schizophrenia and some other neuropsychiatric disorders and proposed as a possible biological marker (endophenotype) for genetic studies. However, little is known about the genetic determination of PPI in humans. We examined acoustic eye-blink startle reflex and PPI in 142 young female twins (40 monozygotic and 31 dizygotic pairs) and conducted a biometrical genetic analysis using structural equation modeling. PPI showed significant heritability suggesting that over 50% of PPI variance in this sample can be attributed to genetic factors. Baseline startle magnitude showed higher heritability (about 70%).

KW - Genetics

KW - Heritability

KW - Prepulse inhibition

KW - Sensorimotor gating

KW - Startle reflex

KW - Twins

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Genetic influences on prepulse inhibition of startle reflex in humans

Abstract

Keywords

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