Genetic influences on frontal brain function: WCST performance in twins

Andrey P. Anokhin; Andrew C. Heath; Angela Ralano

doi:10.1097/00001756-200310270-00019

Genetic influences on frontal brain function: WCST performance in twins

Andrey P. Anokhin, Andrew C. Heath, Angela Ralano

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The Wisconsin Card Sorting Test (WCST) is one of the most widely used assessments of executive functioning related to prefrontal cortex. However, little is known about genetic and environmental determinants of individual differences in WCST performance. This study assessed heritability of standard WCST scores in a sample of 168 young female twins including 58 monozygotic and 25 dizygotic pairs. Several WSCT indices, including the number and percentage of errors, the number of perseverative responses, and the number and percent of perseverative errors, showed significant heritability ranging from 37 to 46%. The results suggest that selected aspects of frontal executive functioning measured by the WCST are moderately influenced by genetic factors.

Original language	English
Pages (from-to)	1975-1978
Number of pages	4
Journal	NeuroReport
Volume	14
Issue number	15
DOIs	https://doi.org/10.1097/00001756-200310270-00019
State	Published - Oct 27 2003

Keywords

Card sorting
Executive functioning
Genetics
Heritability
Prefrontal cortex
Twins

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10.1097/00001756-200310270-00019

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abstract = "The Wisconsin Card Sorting Test (WCST) is one of the most widely used assessments of executive functioning related to prefrontal cortex. However, little is known about genetic and environmental determinants of individual differences in WCST performance. This study assessed heritability of standard WCST scores in a sample of 168 young female twins including 58 monozygotic and 25 dizygotic pairs. Several WSCT indices, including the number and percentage of errors, the number of perseverative responses, and the number and percent of perseverative errors, showed significant heritability ranging from 37 to 46%. The results suggest that selected aspects of frontal executive functioning measured by the WCST are moderately influenced by genetic factors.",

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AB - The Wisconsin Card Sorting Test (WCST) is one of the most widely used assessments of executive functioning related to prefrontal cortex. However, little is known about genetic and environmental determinants of individual differences in WCST performance. This study assessed heritability of standard WCST scores in a sample of 168 young female twins including 58 monozygotic and 25 dizygotic pairs. Several WSCT indices, including the number and percentage of errors, the number of perseverative responses, and the number and percent of perseverative errors, showed significant heritability ranging from 37 to 46%. The results suggest that selected aspects of frontal executive functioning measured by the WCST are moderately influenced by genetic factors.

KW - Card sorting

KW - Executive functioning

KW - Genetics

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KW - Prefrontal cortex

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Genetic influences on frontal brain function: WCST performance in twins

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