TY - JOUR
T1 - Genetic hemochromatosis
T2 - Distribution analysis of six laboratory measures of iron metabolism
AU - Borecki, I. B.
AU - Rao, D. C.
AU - Le Mignon, L.
AU - Yaouanq, J.
AU - Simon, M.
AU - Lalouel, J. M.
PY - 1989
Y1 - 1989
N2 - Six laboratory measures of iron metabolism were studied in a control sample, and a family sample was ascertained on the basis of probands with clinically diagnosed genetic hemochromatosis. The respective distribution of each variable evidenced a mixture of components, presumably arising from the segregation of an HLA-linked locus for hemochromatosis. There were significant differences in the distributional characteristics with respect to sex and genotype-specific variances. These aspects of the data have important implications for subsequent segregation and linkage analyses, which traditionally assume homoscedasticity and homogeneity of the genetic effect.
AB - Six laboratory measures of iron metabolism were studied in a control sample, and a family sample was ascertained on the basis of probands with clinically diagnosed genetic hemochromatosis. The respective distribution of each variable evidenced a mixture of components, presumably arising from the segregation of an HLA-linked locus for hemochromatosis. There were significant differences in the distributional characteristics with respect to sex and genotype-specific variances. These aspects of the data have important implications for subsequent segregation and linkage analyses, which traditionally assume homoscedasticity and homogeneity of the genetic effect.
UR - http://www.scopus.com/inward/record.url?scp=0024378318&partnerID=8YFLogxK
U2 - 10.1002/ajmg.1320340321
DO - 10.1002/ajmg.1320340321
M3 - Article
C2 - 2596531
AN - SCOPUS:0024378318
SN - 0148-7299
VL - 34
SP - 435
EP - 441
JO - American journal of medical genetics
JF - American journal of medical genetics
IS - 3
ER -