Genetic hemochromatosis: Distribution analysis of six laboratory measures of iron metabolism

I. B. Borecki, D. C. Rao, L. Le Mignon, J. Yaouanq, M. Simon, J. M. Lalouel

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Six laboratory measures of iron metabolism were studied in a control sample, and a family sample was ascertained on the basis of probands with clinically diagnosed genetic hemochromatosis. The respective distribution of each variable evidenced a mixture of components, presumably arising from the segregation of an HLA-linked locus for hemochromatosis. There were significant differences in the distributional characteristics with respect to sex and genotype-specific variances. These aspects of the data have important implications for subsequent segregation and linkage analyses, which traditionally assume homoscedasticity and homogeneity of the genetic effect.

Original languageEnglish
Pages (from-to)435-441
Number of pages7
JournalAmerican journal of medical genetics
Volume34
Issue number3
DOIs
StatePublished - Jan 1 1989

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