Genetic factors in cardiac hypertrophy

Gerald W. Dorn, Harvey S. Hahn

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Cardiac hypertrophy is an adaptive response to any cardiac insult or stress that increases hemodynamic load. Cardiac hypertrophy can exist in a state of compensation or progress to a decompensated state (i.e., heart failure) over time. It has been established through transgenic overexpression and gene ablation studies that multiple signaling pathways are involved in the induction of hypertrophy as well as its decompensation. This article reviews the role of Gαq in the development of pressure overload hypertrophy and discusses the relationships between Gαq and β-adrenergic receptors, RGS proteins, and the proapoptotic factor, Nix/Bnip3L.

Original languageEnglish
Pages (from-to)225-237
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume1015
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

Keywords

  • Heart failure
  • Myocardial hypertrophy
  • Receptor signaling

Fingerprint Dive into the research topics of 'Genetic factors in cardiac hypertrophy'. Together they form a unique fingerprint.

  • Cite this