Genetic evolution of a helicobacter pylori acid-sensing histidine kinase and gastric disease

Uma Krishna; Judith Romero-Gallo; Giovanni Suarez; Ayeetin Azah; Andrzej M. Krezel; Matthew G. Varga; Mark H. Forsyth; Richard M. Peek

doi:10.1093/infdis/jiw189

Genetic evolution of a helicobacter pylori acid-sensing histidine kinase and gastric disease

Uma Krishna
, Judith Romero-Gallo
, Giovanni Suarez
, Ayeetin Azah
, Andrzej M. Krezel
, Matthew G. Varga
, Mark H. Forsyth
, Richard M. Peek

Department of Biochemistry & Molecular Biophysics

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer.

Original language	English
Pages (from-to)	644-648
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	214
Issue number	4
DOIs	https://doi.org/10.1093/infdis/jiw189
State	Published - Aug 15 2016

Keywords

Acid resistance
H. pylori
Hypochlorhydia

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10.1093/infdis/jiw189

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title = "Genetic evolution of a helicobacter pylori acid-sensing histidine kinase and gastric disease",

abstract = "Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer.",

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AU - Krishna, Uma

AU - Romero-Gallo, Judith

AU - Suarez, Giovanni

AU - Azah, Ayeetin

AU - Krezel, Andrzej M.

AU - Varga, Matthew G.

AU - Forsyth, Mark H.

AU - Peek, Richard M.

N1 - Publisher Copyright: © The Author 2016.

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N2 - Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer.

AB - Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer.

KW - Acid resistance

KW - H. pylori

KW - Hypochlorhydia

UR - https://www.scopus.com/pages/publications/84988952597

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DO - 10.1093/infdis/jiw189

M3 - Article

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AN - SCOPUS:84988952597

SN - 0022-1899

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EP - 648

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 4

ER -

Genetic evolution of a helicobacter pylori acid-sensing histidine kinase and gastric disease

Abstract

Keywords

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