Genetic evidence for the inactivation of a human autosomal locus attached to an inactive X chromosome

T. Mohandas, R. S. Sparkes, L. J. Shapiro

    Research output: Contribution to journalArticle

    29 Scopus citations

    Abstract

    Mouse-human cell hybrid clones retaining an inactive translocated chromosome involving the human X and 13 were isolated. Esterase D, a marker on the segment of chromosome 13 translocated to the X, was not expressed in these clones. These results provide genetic evidence for the spreading of inactivation into the autosomal segment in an inactive human X-autosome translocation.

    Original languageEnglish
    Pages (from-to)811-817
    Number of pages7
    JournalAmerican journal of human genetics
    Volume34
    Issue number5
    StatePublished - Jan 1 1982

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