L'epidemiologie genetique et la genetique moleculaire de l'obesite: Les enseignements de l'etude des familles de Quebec

Translated title of the contribution: Genetic epidemiology and molecular genetics of obesity: Results from the Quebec Family Study

Louis Pérusse, Yvon C. Chagnon, Treva Rice, D. C. Rao, Claude Bouchard

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Obesity is a complex disease affecting about one third of the adult population in industrialized countries. Research conducted over the past 10 years in the fields of genetic epidemiology and molecular genetics has clearly established that obesity and the susceptibility to gain or lose weight are partly determined by our genes. Based on results from the Quebec Family Study, the heritability of the various obesity phenotypes ranges from about 10% to 50% and segregation analyses suggest that one or a few genes, with an autosomal recessive mode of inheritance, have a major effect on these phenotypes. The current human obesity gene map based on results from animal and human studies indicates that all chromosomes, with the exception of the Y chromosome, include genes or loci potentially involved in the etiology of obesity.

Translated title of the contributionGenetic epidemiology and molecular genetics of obesity: Results from the Quebec Family Study
Original languageFrench
Pages (from-to)914-924
Number of pages11
JournalMedecine/Sciences
Volume14
Issue number8-9
StatePublished - Aug 1998

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