Genetic Discovery of ATP-Sensitive K+ Channels in Cardiovascular Diseases

Yan Huang, Dan Hu, Congxin Huang, Colin G. Nichols

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

The ATP-sensitive K+ (KATP) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K+ channel subtypes in physiological and pathological processes in a variety of cardiovascular diseases. In this review, we focus on the causal relationship between ATP-sensitive K+ channel activity and pathophysiology in the cardiovascular system, particularly from the perspective of genetic changes in human and animal models.

Original languageEnglish
Article numbere007322
JournalCirculation: Arrhythmia and Electrophysiology
Volume12
Issue number5
DOIs
StatePublished - May 1 2019

Keywords

  • cardiovascular diseases
  • cardiovascular system
  • heart failure
  • neuron
  • sulfonylurea receptor

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