TY - JOUR
T1 - Genetic Discovery of ATP-Sensitive K+ Channels in Cardiovascular Diseases
AU - Huang, Yan
AU - Hu, Dan
AU - Huang, Congxin
AU - Nichols, Colin G.
N1 - Publisher Copyright:
© 2019 American Heart Association, Inc.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - The ATP-sensitive K+ (KATP) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K+ channel subtypes in physiological and pathological processes in a variety of cardiovascular diseases. In this review, we focus on the causal relationship between ATP-sensitive K+ channel activity and pathophysiology in the cardiovascular system, particularly from the perspective of genetic changes in human and animal models.
AB - The ATP-sensitive K+ (KATP) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K+ channel subtypes in physiological and pathological processes in a variety of cardiovascular diseases. In this review, we focus on the causal relationship between ATP-sensitive K+ channel activity and pathophysiology in the cardiovascular system, particularly from the perspective of genetic changes in human and animal models.
KW - cardiovascular diseases
KW - cardiovascular system
KW - heart failure
KW - neuron
KW - sulfonylurea receptor
UR - http://www.scopus.com/inward/record.url?scp=85065252628&partnerID=8YFLogxK
U2 - 10.1161/CIRCEP.119.007322
DO - 10.1161/CIRCEP.119.007322
M3 - Review article
C2 - 31030551
AN - SCOPUS:85065252628
SN - 1941-3149
VL - 12
JO - Circulation: Arrhythmia and Electrophysiology
JF - Circulation: Arrhythmia and Electrophysiology
IS - 5
M1 - e007322
ER -