Genetic correlation between smoking behaviors and schizophrenia

Sarah M. Hartz; Amy C. Horton; Dana B. Hancock; Timothy B. Baker; Neil E. Caporaso; Li Shiun Chen; John E. Hokanson; Sharon M. Lutz; Mary L. Marazita; Daniel W. McNeil; Carlos N. Pato; Michele T. Pato; Eric O. Johnson; Laura J. Bierut

doi:10.1016/j.schres.2017.02.022

Genetic correlation between smoking behaviors and schizophrenia

Sarah M. Hartz
, Amy C. Horton
, Dana B. Hancock
, Timothy B. Baker
, Neil E. Caporaso
, Li Shiun Chen
, John E. Hokanson
, Sharon M. Lutz
, Mary L. Marazita
, Daniel W. McNeil
, Carlos N. Pato
, Michele T. Pato
, Eric O. Johnson
, Laura J. Bierut

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N = 74,035), age of onset of smoking (N = 28,647), cigarettes smoked per day (CPD, N = 38,860), nicotine dependence (N = 10,666), and current/former smoker (N = 40,562)) were compared to GWAS meta-analysis results from schizophrenia (N = 79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h² _g) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h² _g = 0.08, age of onset of smoking h² _g = 0.06, CPD h² _g = 0.06, nicotine dependence h² _g = 0.15, current/former smoker h² _g = 0.07, p < 0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p < 0.0005 for all two-way comparisons). Next, a statistically significant (p < 0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r_g = 0.14, CPD r_g = 0.12, and ever/never smoking r_g = 0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia.

Original language	English
Pages (from-to)	86-90
Number of pages	5
Journal	Schizophrenia research
Volume	194
DOIs	https://doi.org/10.1016/j.schres.2017.02.022
State	Published - Apr 2018

Keywords

Genetic correlation
Nicotine dependence
Schizophrenia

Access to Document

10.1016/j.schres.2017.02.022

Cite this

@article{ea670a9aa2fe43758b4a6df3fa380e63,

title = "Genetic correlation between smoking behaviors and schizophrenia",

abstract = "Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N = 74,035), age of onset of smoking (N = 28,647), cigarettes smoked per day (CPD, N = 38,860), nicotine dependence (N = 10,666), and current/former smoker (N = 40,562)) were compared to GWAS meta-analysis results from schizophrenia (N = 79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h2 g) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h2 g = 0.08, age of onset of smoking h2 g = 0.06, CPD h2 g = 0.06, nicotine dependence h2 g = 0.15, current/former smoker h2 g = 0.07, p < 0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p < 0.0005 for all two-way comparisons). Next, a statistically significant (p < 0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence rg = 0.14, CPD rg = 0.12, and ever/never smoking rg = 0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia.",

keywords = "Genetic correlation, Nicotine dependence, Schizophrenia",

author = "Hartz, \{Sarah M.\} and Horton, \{Amy C.\} and Hancock, \{Dana B.\} and Baker, \{Timothy B.\} and Caporaso, \{Neil E.\} and Chen, \{Li Shiun\} and Hokanson, \{John E.\} and Lutz, \{Sharon M.\} and Marazita, \{Mary L.\} and McNeil, \{Daniel W.\} and Pato, \{Carlos N.\} and Pato, \{Michele T.\} and Johnson, \{Eric O.\} and Bierut, \{Laura J.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = apr,

doi = "10.1016/j.schres.2017.02.022",

language = "English",

volume = "194",

pages = "86--90",

journal = "Schizophrenia research",

issn = "0920-9964",

}

TY - JOUR

T1 - Genetic correlation between smoking behaviors and schizophrenia

AU - Hartz, Sarah M.

AU - Horton, Amy C.

AU - Hancock, Dana B.

AU - Baker, Timothy B.

AU - Caporaso, Neil E.

AU - Chen, Li Shiun

AU - Hokanson, John E.

AU - Lutz, Sharon M.

AU - Marazita, Mary L.

AU - McNeil, Daniel W.

AU - Pato, Carlos N.

AU - Pato, Michele T.

AU - Johnson, Eric O.

AU - Bierut, Laura J.

PY - 2018/4

Y1 - 2018/4

N2 - Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N = 74,035), age of onset of smoking (N = 28,647), cigarettes smoked per day (CPD, N = 38,860), nicotine dependence (N = 10,666), and current/former smoker (N = 40,562)) were compared to GWAS meta-analysis results from schizophrenia (N = 79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h2 g) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h2 g = 0.08, age of onset of smoking h2 g = 0.06, CPD h2 g = 0.06, nicotine dependence h2 g = 0.15, current/former smoker h2 g = 0.07, p < 0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p < 0.0005 for all two-way comparisons). Next, a statistically significant (p < 0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence rg = 0.14, CPD rg = 0.12, and ever/never smoking rg = 0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia.

AB - Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N = 74,035), age of onset of smoking (N = 28,647), cigarettes smoked per day (CPD, N = 38,860), nicotine dependence (N = 10,666), and current/former smoker (N = 40,562)) were compared to GWAS meta-analysis results from schizophrenia (N = 79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h2 g) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h2 g = 0.08, age of onset of smoking h2 g = 0.06, CPD h2 g = 0.06, nicotine dependence h2 g = 0.15, current/former smoker h2 g = 0.07, p < 0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p < 0.0005 for all two-way comparisons). Next, a statistically significant (p < 0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence rg = 0.14, CPD rg = 0.12, and ever/never smoking rg = 0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia.

KW - Genetic correlation

KW - Nicotine dependence

KW - Schizophrenia

UR - https://www.scopus.com/pages/publications/85015789839

U2 - 10.1016/j.schres.2017.02.022

DO - 10.1016/j.schres.2017.02.022

M3 - Article

C2 - 28285025

AN - SCOPUS:85015789839

SN - 0920-9964

VL - 194

SP - 86

EP - 90

JO - Schizophrenia research

JF - Schizophrenia research

ER -

Genetic correlation between smoking behaviors and schizophrenia

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this