Genetic correlation between smoking behaviors and schizophrenia

Sarah M. Hartz; Amy C. Horton; Dana B. Hancock; Timothy B. Baker; Neil E. Caporaso; Li Shiun Chen; John E. Hokanson; Sharon M. Lutz; Mary L. Marazita; Daniel W. McNeil; Carlos N. Pato; Michele T. Pato; Eric O. Johnson; Laura J. Bierut

doi:10.1016/j.schres.2017.02.022

Genetic correlation between smoking behaviors and schizophrenia

Sarah M. Hartz, Amy C. Horton, Dana B. Hancock, Timothy B. Baker, Neil E. Caporaso, Li Shiun Chen, John E. Hokanson, Sharon M. Lutz, Mary L. Marazita, Daniel W. McNeil, Carlos N. Pato, Michele T. Pato, Eric O. Johnson, Laura J. Bierut

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55 Scopus citations

Abstract

Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N = 74,035), age of onset of smoking (N = 28,647), cigarettes smoked per day (CPD, N = 38,860), nicotine dependence (N = 10,666), and current/former smoker (N = 40,562)) were compared to GWAS meta-analysis results from schizophrenia (N = 79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h² _g) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h² _g = 0.08, age of onset of smoking h² _g = 0.06, CPD h² _g = 0.06, nicotine dependence h² _g = 0.15, current/former smoker h² _g = 0.07, p < 0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p < 0.0005 for all two-way comparisons). Next, a statistically significant (p < 0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r_g = 0.14, CPD r_g = 0.12, and ever/never smoking r_g = 0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia.

Original language	English
Pages (from-to)	86-90
Number of pages	5
Journal	Schizophrenia research
Volume	194
DOIs	https://doi.org/10.1016/j.schres.2017.02.022
State	Published - Apr 2018

Keywords

Genetic correlation
Nicotine dependence
Schizophrenia

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10.1016/j.schres.2017.02.022

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@article{ea670a9aa2fe43758b4a6df3fa380e63,

title = "Genetic correlation between smoking behaviors and schizophrenia",

abstract = "Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N = 74,035), age of onset of smoking (N = 28,647), cigarettes smoked per day (CPD, N = 38,860), nicotine dependence (N = 10,666), and current/former smoker (N = 40,562)) were compared to GWAS meta-analysis results from schizophrenia (N = 79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h2 g) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h2 g = 0.08, age of onset of smoking h2 g = 0.06, CPD h2 g = 0.06, nicotine dependence h2 g = 0.15, current/former smoker h2 g = 0.07, p < 0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p < 0.0005 for all two-way comparisons). Next, a statistically significant (p < 0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence rg = 0.14, CPD rg = 0.12, and ever/never smoking rg = 0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia.",

keywords = "Genetic correlation, Nicotine dependence, Schizophrenia",

author = "Hartz, {Sarah M.} and Horton, {Amy C.} and Hancock, {Dana B.} and Baker, {Timothy B.} and Caporaso, {Neil E.} and Chen, {Li Shiun} and Hokanson, {John E.} and Lutz, {Sharon M.} and Marazita, {Mary L.} and McNeil, {Daniel W.} and Pato, {Carlos N.} and Pato, {Michele T.} and Johnson, {Eric O.} and Bierut, {Laura J.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = apr,

doi = "10.1016/j.schres.2017.02.022",

language = "English",

volume = "194",

pages = "86--90",

journal = "Schizophrenia research",

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TY - JOUR

T1 - Genetic correlation between smoking behaviors and schizophrenia

AU - Hartz, Sarah M.

AU - Horton, Amy C.

AU - Hancock, Dana B.

AU - Baker, Timothy B.

AU - Caporaso, Neil E.

AU - Chen, Li Shiun

AU - Hokanson, John E.

AU - Lutz, Sharon M.

AU - Marazita, Mary L.

AU - McNeil, Daniel W.

AU - Pato, Carlos N.

AU - Pato, Michele T.

AU - Johnson, Eric O.

AU - Bierut, Laura J.

PY - 2018/4

Y1 - 2018/4

N2 - Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N = 74,035), age of onset of smoking (N = 28,647), cigarettes smoked per day (CPD, N = 38,860), nicotine dependence (N = 10,666), and current/former smoker (N = 40,562)) were compared to GWAS meta-analysis results from schizophrenia (N = 79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h2 g) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h2 g = 0.08, age of onset of smoking h2 g = 0.06, CPD h2 g = 0.06, nicotine dependence h2 g = 0.15, current/former smoker h2 g = 0.07, p < 0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p < 0.0005 for all two-way comparisons). Next, a statistically significant (p < 0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence rg = 0.14, CPD rg = 0.12, and ever/never smoking rg = 0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia.

AB - Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N = 74,035), age of onset of smoking (N = 28,647), cigarettes smoked per day (CPD, N = 38,860), nicotine dependence (N = 10,666), and current/former smoker (N = 40,562)) were compared to GWAS meta-analysis results from schizophrenia (N = 79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h2 g) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h2 g = 0.08, age of onset of smoking h2 g = 0.06, CPD h2 g = 0.06, nicotine dependence h2 g = 0.15, current/former smoker h2 g = 0.07, p < 0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p < 0.0005 for all two-way comparisons). Next, a statistically significant (p < 0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence rg = 0.14, CPD rg = 0.12, and ever/never smoking rg = 0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia.

KW - Genetic correlation

KW - Nicotine dependence

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85015789839&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2017.02.022

DO - 10.1016/j.schres.2017.02.022

M3 - Article

C2 - 28285025

AN - SCOPUS:85015789839

SN - 0920-9964

VL - 194

SP - 86

EP - 90

JO - Schizophrenia research

JF - Schizophrenia research

ER -

Genetic correlation between smoking behaviors and schizophrenia

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Keywords

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