TY - JOUR
T1 - Genetic control of uterine receptivity during implantation
AU - Ma, Liang
AU - Yao, Mylene
AU - Maas, Richard L.
PY - 1999
Y1 - 1999
N2 - Implantation involves complex molecular interactions between implanting blastocysts and the hormonally primed uterus. Gene targeting allows the generation of mice lacking a specific gene or genes and has proved to be of considerable value when combined with classical physiology in understanding many biological questions, such as the process of implantation. In this article, we review genes that have been demonstrated by gene targeting in mice to be required in the uterus for implantation. In particular, we focus on a specific class of developmental control genes, the mammalian Hox genes, and their role in this process. Lastly, we attempt to synthesize current knowledge about the genetic control of implantation and to build a working genetic model for the implantation pathway.
AB - Implantation involves complex molecular interactions between implanting blastocysts and the hormonally primed uterus. Gene targeting allows the generation of mice lacking a specific gene or genes and has proved to be of considerable value when combined with classical physiology in understanding many biological questions, such as the process of implantation. In this article, we review genes that have been demonstrated by gene targeting in mice to be required in the uterus for implantation. In particular, we focus on a specific class of developmental control genes, the mammalian Hox genes, and their role in this process. Lastly, we attempt to synthesize current knowledge about the genetic control of implantation and to build a working genetic model for the implantation pathway.
KW - Estrogen
KW - Hox
KW - Implantation
KW - Progesterone
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=0032787397&partnerID=8YFLogxK
U2 - 10.1055/s-2007-1016228
DO - 10.1055/s-2007-1016228
M3 - Review article
C2 - 10797939
AN - SCOPUS:0032787397
SN - 0734-8630
VL - 17
SP - 205
EP - 216
JO - Seminars in Reproductive Endocrinology
JF - Seminars in Reproductive Endocrinology
IS - 3
ER -