Genetic control of interleukin 12 responsiveness: Implications for disease pathogenesis

James D. Gorham; Mehmet L. Güler; Kenneth M. Murphy

doi:10.1007/s001090050135

Genetic control of interleukin 12 responsiveness: Implications for disease pathogenesis

James D. Gorham, Mehmet L. Güler, Kenneth M. Murphy

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysis of the differential control of IL-12 responsiveness led to the identification of a controlling locus on the middle portion of murine chromosome 11. This genetic region (or its human counterpart, 5q31) has been associated with increased disease susceptibilities for several atopic, infectious, and autoimmune disorders. We discuss potential roles for genetic control of IL-12 responsiveness in the development of these diseases.

Original language	English
Pages (from-to)	502-511
Number of pages	10
Journal	Journal of Molecular Medicine
Volume	75
Issue number	7
DOIs	https://doi.org/10.1007/s001090050135
State	Published - 1997

Keywords

Allergy
Autoimmunity
Genetics
Interleukin 12
Leishmania
T helper 1/T helper 2

Access to Document

10.1007/s001090050135

Cite this

@article{04ec6051be7841ecb91389ff13fdf4b2,

title = "Genetic control of interleukin 12 responsiveness: Implications for disease pathogenesis",

abstract = "We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysis of the differential control of IL-12 responsiveness led to the identification of a controlling locus on the middle portion of murine chromosome 11. This genetic region (or its human counterpart, 5q31) has been associated with increased disease susceptibilities for several atopic, infectious, and autoimmune disorders. We discuss potential roles for genetic control of IL-12 responsiveness in the development of these diseases.",

keywords = "Allergy, Autoimmunity, Genetics, Interleukin 12, Leishmania, T helper 1/T helper 2",

author = "Gorham, {James D.} and G{\"u}ler, {Mehmet L.} and Murphy, {Kenneth M.}",

year = "1997",

doi = "10.1007/s001090050135",

language = "English",

volume = "75",

pages = "502--511",

journal = "Journal of Molecular Medicine",

issn = "0946-2716",

number = "7",

}

TY - JOUR

T1 - Genetic control of interleukin 12 responsiveness

T2 - Implications for disease pathogenesis

AU - Gorham, James D.

AU - Güler, Mehmet L.

AU - Murphy, Kenneth M.

PY - 1997

Y1 - 1997

N2 - We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysis of the differential control of IL-12 responsiveness led to the identification of a controlling locus on the middle portion of murine chromosome 11. This genetic region (or its human counterpart, 5q31) has been associated with increased disease susceptibilities for several atopic, infectious, and autoimmune disorders. We discuss potential roles for genetic control of IL-12 responsiveness in the development of these diseases.

AB - We examined the effect of genetic background on Th1/Th2 development. We discuss data demonstrating that genetic background is an important determinant of interleukin-12 (IL-12) responsiveness and the potential implications for disease progression in murine experimental leishmaniasis. Genetic analysis of the differential control of IL-12 responsiveness led to the identification of a controlling locus on the middle portion of murine chromosome 11. This genetic region (or its human counterpart, 5q31) has been associated with increased disease susceptibilities for several atopic, infectious, and autoimmune disorders. We discuss potential roles for genetic control of IL-12 responsiveness in the development of these diseases.

KW - Allergy

KW - Autoimmunity

KW - Genetics

KW - Interleukin 12

KW - Leishmania

KW - T helper 1/T helper 2

UR - http://www.scopus.com/inward/record.url?scp=0030871759&partnerID=8YFLogxK

U2 - 10.1007/s001090050135

DO - 10.1007/s001090050135

M3 - Review article

C2 - 9253713

AN - SCOPUS:0030871759

SN - 0946-2716

VL - 75

SP - 502

EP - 511

JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

IS - 7

ER -

Genetic control of interleukin 12 responsiveness: Implications for disease pathogenesis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this