TY - JOUR
T1 - Genetic control of Drosophila nerve cord development
AU - Skeath, James B.
AU - Thor, Stefan
N1 - Funding Information:
We thank Osa Thor for making Figure 1 , and Bill Chia, Ward Odenwald and Doug W Allan for constructive criticism of the manuscript. Research in the authors’ laboratories is supported by grants from the National Institutes of Health, The Lefler, Armenise, Harcourt/Cox Medical and Freudenberger Foundations to Stefan Thor, and by grants from the National Institutes of Health, National Science Foundation and the National Aeronautics and Space Administration to James B Skeath.
PY - 2003/2
Y1 - 2003/2
N2 - The Drosophila ventral nerve cord has been a central model system for studying the molecular genetic mechanisms that control CNS development. Studies show that the generation of neural diversity is a multistep process initiated by the patterning and segmentation of the neuroectoderm. These events act together with the process of lateral inhibition to generate precursor cells (neuroblasts) with specific identities, distinguished by the expression of unique combinations of regulatory genes. The expression of these genes in a given neuroblast restricts the fate of its progeny, by activating specific combinations of downstream genes. These genes in turn specify the identity of any given postmitotic cell, which is evident by its cellular morphology and choice of neurotransmitter.
AB - The Drosophila ventral nerve cord has been a central model system for studying the molecular genetic mechanisms that control CNS development. Studies show that the generation of neural diversity is a multistep process initiated by the patterning and segmentation of the neuroectoderm. These events act together with the process of lateral inhibition to generate precursor cells (neuroblasts) with specific identities, distinguished by the expression of unique combinations of regulatory genes. The expression of these genes in a given neuroblast restricts the fate of its progeny, by activating specific combinations of downstream genes. These genes in turn specify the identity of any given postmitotic cell, which is evident by its cellular morphology and choice of neurotransmitter.
UR - http://www.scopus.com/inward/record.url?scp=0037322317&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(03)00007-2
DO - 10.1016/S0959-4388(03)00007-2
M3 - Review article
C2 - 12593977
AN - SCOPUS:0037322317
SN - 0959-4388
VL - 13
SP - 8
EP - 15
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 1
ER -