Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor

John H. Russell; Claraine B. Dobos; Ralph J. Graff; Benjamin A. Taylor

doi:10.1007/BF00342195

Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor

John H. Russell, Claraine B. Dobos, Ralph J. Graff, Benjamin A. Taylor

Department of Developmental Biology

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Abstract

Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.

Original language	English
Pages (from-to)	263-272
Number of pages	10
Journal	Immunogenetics
Volume	14
Issue number	3-4
DOIs	https://doi.org/10.1007/BF00342195
State	Published - Oct 1981

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abstract = "Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.",

author = "Russell, {John H.} and Dobos, {Claraine B.} and Graff, {Ralph J.} and Taylor, {Benjamin A.}",

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AU - Dobos, Claraine B.

AU - Graff, Ralph J.

AU - Taylor, Benjamin A.

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AB - Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.

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ER -

Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor

Abstract

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