Genetic buffering mechanisms in SNF2-family translocases

Sumedha Agashe; Alessandro Vindigni

doi:10.1016/j.tig.2025.01.005

Genetic buffering mechanisms in SNF2-family translocases

Sumedha Agashe
, Alessandro Vindigni

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles in genomic stability. In a recent study, Feng et al. identified a synthetic lethal interaction between the SNF2 translocase SMARCAL1 and Fanconi anemia (FA) group M (FANCM), revealing a new genetic buffering mechanism that maintains genome stability by aiding DNA replication at loci enriched in simple repeats.

Original language	English
Pages (from-to)	266-267
Number of pages	2
Journal	Trends in Genetics
Volume	41
Issue number	4
DOIs	https://doi.org/10.1016/j.tig.2025.01.005
State	Published - Apr 2025

Keywords

SNF2-family DNA translocases
simple repeats

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10.1016/j.tig.2025.01.005

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title = "Genetic buffering mechanisms in SNF2-family translocases",

abstract = "SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles in genomic stability. In a recent study, Feng et al. identified a synthetic lethal interaction between the SNF2 translocase SMARCAL1 and Fanconi anemia (FA) group M (FANCM), revealing a new genetic buffering mechanism that maintains genome stability by aiding DNA replication at loci enriched in simple repeats.",

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AU - Agashe, Sumedha

AU - Vindigni, Alessandro

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N2 - SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles in genomic stability. In a recent study, Feng et al. identified a synthetic lethal interaction between the SNF2 translocase SMARCAL1 and Fanconi anemia (FA) group M (FANCM), revealing a new genetic buffering mechanism that maintains genome stability by aiding DNA replication at loci enriched in simple repeats.

AB - SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles in genomic stability. In a recent study, Feng et al. identified a synthetic lethal interaction between the SNF2 translocase SMARCAL1 and Fanconi anemia (FA) group M (FANCM), revealing a new genetic buffering mechanism that maintains genome stability by aiding DNA replication at loci enriched in simple repeats.

KW - SNF2-family DNA translocases

KW - simple repeats

UR - https://www.scopus.com/pages/publications/85216546294

U2 - 10.1016/j.tig.2025.01.005

DO - 10.1016/j.tig.2025.01.005

M3 - Short survey

C2 - 39890571

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SP - 266

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JO - Trends in Genetics

JF - Trends in Genetics

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ER -

Genetic buffering mechanisms in SNF2-family translocases

Abstract

Keywords

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