TY - JOUR
T1 - Genetic buffering mechanisms in SNF2-family translocases
AU - Agashe, Sumedha
AU - Vindigni, Alessandro
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2025/4
Y1 - 2025/4
N2 - SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles in genomic stability. In a recent study, Feng et al. identified a synthetic lethal interaction between the SNF2 translocase SMARCAL1 and Fanconi anemia (FA) group M (FANCM), revealing a new genetic buffering mechanism that maintains genome stability by aiding DNA replication at loci enriched in simple repeats.
AB - SNF2-family DNA translocases, a large family of ATPases, have poorly defined roles in genomic stability. In a recent study, Feng et al. identified a synthetic lethal interaction between the SNF2 translocase SMARCAL1 and Fanconi anemia (FA) group M (FANCM), revealing a new genetic buffering mechanism that maintains genome stability by aiding DNA replication at loci enriched in simple repeats.
KW - SNF2-family DNA translocases
KW - simple repeats
UR - http://www.scopus.com/inward/record.url?scp=85216546294&partnerID=8YFLogxK
U2 - 10.1016/j.tig.2025.01.005
DO - 10.1016/j.tig.2025.01.005
M3 - Short survey
C2 - 39890571
AN - SCOPUS:85216546294
SN - 0168-9525
VL - 41
SP - 266
EP - 267
JO - Trends in Genetics
JF - Trends in Genetics
IS - 4
ER -