11 Scopus citations

Abstract

Genetic association studies have a long history of delivering insightful results for cardiovascular disease (CVD) research. Beginning with early candidate gene studies, to genome-wide association studies, and now on to newer whole-genome sequencing studies, research in human genetics has enriched our understanding of the pathobiology of CVD. As these studies continue to expand, the issue of statistical power plays an important role in study design as well as the interpretation of results. We provide an overview of the component parts that determine statistical power and preview the future of CVD genetic association studies through this lens.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalTrends in Cardiovascular Medicine
Volume27
Issue number6
DOIs
StatePublished - Aug 2017

Keywords

  • GWAS
  • Genetics
  • Power

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