@article{a6470894d4c6435d80bf22f7413edac2,
title = "Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults",
abstract = "Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence. The subjects were 2,938 adolescents and young adults ages 12-25. Results showed that the CHRM2 gene variants and ERO risk factors had hazards which varied considerably with age. The bulk of the significant age-specific associations occurred in those whose age of onset was under 16. These associations were concentrated in those subjects who at some time took an illicit drug. These results are consistent with studies which associate greater rates of alcohol dependence among those who begin drinking at an early age. The age specificity of the genetic and neurophysiological factors is consistent with recent studies of adolescent brain development, which locate an interval of heightened vulnerability to substance use disorders in the early to mid teens.",
keywords = "Adolescents, Alcoholism, CHRM2, ERO, Genetics, Survival analysis",
author = "Chorlian, {David B.} and Madhavi Rangaswamy and Niklas Manz and Wang, {Jen Chyong} and Danielle Dick and Laura Almasy and Lance Bauer and Kathleen Bucholz and Tatiana Foroud and Victor Hesselbrock and Kang, {Sun J.} and John Kramer and Sam Kuperman and John Nurnberger and John Rice and Marc Schuckit and Jay Tischfield and Edenberg, {Howard J.} and Alison Goate and Laura Bierut and Bernice Porjesz",
note = "Funding Information: Principal Investigators: B. Porjesz, V. Hesselbrock, H. Edenberg, L. Bierut, includes 10 different centers: University of Connecticut (V. Hesselbrock); Indiana University (H.J. Edenberg, J. Nurnberger Jr., T. Foroud); University of Iowa (S. Kuperman, J. Kramer); SUNY Downstate (B. Porjesz); Washington University in St. Louis (L. Bierut, A. Goate, J. Rice, K. Bucholz); University of California at San Diego (M. Schuckit); Rutgers University (J. Tischfield); Texas Biomedical Research Institute (L. Almasy), Howard University (R. Taylor) and Virginia Commonwealth University (D. Dick). Other COGA collaborators include: L. Bauer (University of Connecticut); D. Koller, S. O{\textquoteright}Connor, L. Wetherill, X. Xuei (Indiana University); Grace Chan (University of Iowa); S. Kang, N. Manz, M. Rangaswamy (SUNY Downstate); J. Rohrbaugh, J.-C. Wang (Washington University in St. Louis); A. Brooks (Rutgers University); and F. Aliev (Virginia Commonwealth University) A. Parsian and M. Reilly are the NIAAA Staff Collaborators. We continue to be inspired by our memories of Henri Begleiter and Theodore Reich, founding PI and Co-PI of COGA, and also owe a debt of gratitude to other past organizers of COGA, including Ting-Kai Li, currently a consultant with COGA, P. Michael Conneally, Raymond Crowe, and Wendy Reich, for their critical contributions. This national collaborative study is supported by NIH Grant U10AA008401 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA).",
year = "2013",
month = sep,
doi = "10.1007/s10519-013-9604-z",
language = "English",
volume = "43",
pages = "386--401",
journal = "Behavior Genetics",
issn = "0001-8244",
number = "5",
}