TY - JOUR
T1 - Genetic and epigenetic regulation of IgH gene assembly
AU - Sen, Ranjan
AU - Oltz, Eugene
N1 - Funding Information:
RS is supported by the Intramural Research Program of the National Institute on Aging, Baltimore, MD. EO is supported by grants from the National Institutes of Health.
PY - 2006/6
Y1 - 2006/6
N2 - Precursor B cells assemble a diverse repertoire of immunoglobulin (Ig) genes by the process of V(D)J recombination. Assembly of IgH genes is regulated in a tissue- and stage-specific manner via the activation and then the inactivation of distinct regions within the one megabase IgH locus. Recent studies have shown that regional control is achieved using a combination of genetic and epigenetic strategies, which modulate chromatin accessibility to V(D)J recombinase, relocate IgH loci within the nucleus, and promote changes in locus conformation that alter the spatial proximity of target gene segments. Orchestration of these regulatory processes is crucial for the generation of a functional B cell repertoire.
AB - Precursor B cells assemble a diverse repertoire of immunoglobulin (Ig) genes by the process of V(D)J recombination. Assembly of IgH genes is regulated in a tissue- and stage-specific manner via the activation and then the inactivation of distinct regions within the one megabase IgH locus. Recent studies have shown that regional control is achieved using a combination of genetic and epigenetic strategies, which modulate chromatin accessibility to V(D)J recombinase, relocate IgH loci within the nucleus, and promote changes in locus conformation that alter the spatial proximity of target gene segments. Orchestration of these regulatory processes is crucial for the generation of a functional B cell repertoire.
UR - http://www.scopus.com/inward/record.url?scp=33646163470&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2006.03.008
DO - 10.1016/j.coi.2006.03.008
M3 - Review article
C2 - 16616470
AN - SCOPUS:33646163470
SN - 0952-7915
VL - 18
SP - 237
EP - 242
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 3
ER -