Genetic and environmental contributions to smoking

William R. True, Andrew C. Heath, Jeffrey F. Scherrer, Brian Waterman, Jack Goldberg, Nong Lin, Seth A. Eisen, Michael J. Lyons, Ming T. Tsuang

Research output: Contribution to journalArticlepeer-review

219 Scopus citations

Abstract

We estimate the magnitude of genetic and shared environmental contributions to risk of initiation and maintenance of smoking. Genetic models were fitted to data from 2204 male-male monozygotic and 1793 male-male dizygotic twin pairs from the Vietnam Era Twin Registry who responded to smoking questions on a 1987 mail and telephone survey. The best fitting model allowed for both genetic and shared environmental effects on smoking initiation, accounting for 50% and 30% of the variance in risk, but allowed for only genetic effects, (accounting for 70% of the variance in risk), on persistence in smoking among those who had become regular smokers. This finding of a major genetic influence on smoking persistence confirms similar results from studies in Scandinavia and Australia. The role of heritable traits such as nicotine sensitivity should be addressed in smoking prevention and cessation efforts.

Original languageEnglish
Pages (from-to)1277-1287
Number of pages11
JournalAddiction
Volume92
Issue number10
DOIs
StatePublished - 1997

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