Genetic ancestry correlations with driver mutations suggest complex interactions between somatic and germline variation in cancer

Felicia Gomez; Malachi Griffith; Obi L. Griffith

doi:10.1158/2159-8290.CD-21-0092

Genetic ancestry correlations with driver mutations suggest complex interactions between somatic and germline variation in cancer

Felicia Gomez, Malachi Griffith, Obi L. Griffith

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Carrot-Zhang and colleagues describe associations between Native American ancestry and the somatic mutational landscape in lung cancer, including tumor mutation burden and specific driver mutations in EGFR, KRAS, and STK11. Local ancestry analysis suggests that specific germline loci, and not environment, underlie these associations.

Original language	English
Pages (from-to)	534-536
Number of pages	3
Journal	Cancer discovery
Volume	11
Issue number	3
DOIs	https://doi.org/10.1158/2159-8290.CD-21-0092
State	Published - Mar 2021

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title = "Genetic ancestry correlations with driver mutations suggest complex interactions between somatic and germline variation in cancer",

abstract = "Carrot-Zhang and colleagues describe associations between Native American ancestry and the somatic mutational landscape in lung cancer, including tumor mutation burden and specific driver mutations in EGFR, KRAS, and STK11. Local ancestry analysis suggests that specific germline loci, and not environment, underlie these associations.",

author = "Felicia Gomez and Malachi Griffith and Griffith, {Obi L.}",

note = "Publisher Copyright: {\textcopyright} 2021 American Association for Cancer Research.",

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AU - Griffith, Malachi

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AB - Carrot-Zhang and colleagues describe associations between Native American ancestry and the somatic mutational landscape in lung cancer, including tumor mutation burden and specific driver mutations in EGFR, KRAS, and STK11. Local ancestry analysis suggests that specific germline loci, and not environment, underlie these associations.

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Genetic ancestry correlations with driver mutations suggest complex interactions between somatic and germline variation in cancer

Abstract

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