Genetic analysis combining path analysis with regressive models: The TAU model of multifactorial transmission

Complement component C7 plays an important role in the for-mation of the membrane attack complex of the complement system. Here we describe a novel polymorphism of human C7, namely a nucleotide sequence polymorphism changing codon 367 from AGT (encoding Ser) to ACT (encoding Thr). Using the polymerase chain reaction, the polymorphism is easily detectable either as a Mae III restriction fragment length polymorphism or by single-strand conformation analysis. The two alleles are both very common, probably in all major races.