Genetic analysis combining path analysis with regressive models: The TAU model of multifactorial transmission

Zhaohai Li, George E. Bonney, G. M. Lathrop, D. C. Rao

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Complement component C7 plays an important role in the for-mation of the membrane attack complex of the complement system. Here we describe a novel polymorphism of human C7, namely a nucleotide sequence polymorphism changing codon 367 from AGT (encoding Ser) to ACT (encoding Thr). Using the polymerase chain reaction, the polymorphism is easily detectable either as a Mae III restriction fragment length polymorphism or by single-strand conformation analysis. The two alleles are both very common, probably in all major races.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalHuman heredity
Volume44
Issue number6
DOIs
StatePublished - 1994

Keywords

  • Heritability
  • Path analysis
  • Regressive model
  • Segregation analysis
  • Tau path model

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