Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells

Partha P. Manna; Andrés Jaramillo; Kanchana Majumder; Lacey G. Campbell; Timothy P. Fleming; Jill R. Dietz; John F. Dipersio; T. Mohanakumar

doi:10.1023/A:1023323509888

Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells

Partha P. Manna
, Andrés Jaramillo
, Kanchana Majumder
, Lacey G. Campbell
, Timothy P. Fleming
, Jill R. Dietz
, John F. Dipersio
, T. Mohanakumar

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.

Original language	English
Pages (from-to)	133-136
Number of pages	4
Journal	Breast Cancer Research and Treatment
Volume	79
Issue number	1
DOIs	https://doi.org/10.1023/A:1023323509888
State	Published - May 2003

Keywords

CD8+ T lymphocytes
Cytotoxic activity
Dendritic cells
Mammaglobin-A
Tumor-specific antigen

Access to Document

10.1023/A:1023323509888

Cite this

@article{5ab68adc28e04a50a0e14e49bc30f691,

title = "Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells",

abstract = "Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.",

keywords = "CD8+ T lymphocytes, Cytotoxic activity, Dendritic cells, Mammaglobin-A, Tumor-specific antigen",

author = "Manna, \{Partha P.\} and Andr{\'e}s Jaramillo and Kanchana Majumder and Campbell, \{Lacey G.\} and Fleming, \{Timothy P.\} and Dietz, \{Jill R.\} and Dipersio, \{John F.\} and T. Mohanakumar",

year = "2003",

month = may,

doi = "10.1023/A:1023323509888",

language = "English",

volume = "79",

pages = "133--136",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

number = "1",

}

TY - JOUR

T1 - Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells

AU - Manna, Partha P.

AU - Jaramillo, Andrés

AU - Majumder, Kanchana

AU - Campbell, Lacey G.

AU - Fleming, Timothy P.

AU - Dietz, Jill R.

AU - Dipersio, John F.

AU - Mohanakumar, T.

PY - 2003/5

Y1 - 2003/5

N2 - Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.

AB - Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.

KW - CD8+ T lymphocytes

KW - Cytotoxic activity

KW - Dendritic cells

KW - Mammaglobin-A

KW - Tumor-specific antigen

UR - https://www.scopus.com/pages/publications/0037689046

U2 - 10.1023/A:1023323509888

DO - 10.1023/A:1023323509888

M3 - Article

C2 - 12779090

AN - SCOPUS:0037689046

SN - 0167-6806

VL - 79

SP - 133

EP - 136

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 1

ER -

Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this