Generation of anatomically realistic numerical phantoms for optoacoustic breast imaging

Yang Lou, Kenji Mitsuhashi, Catherine M. Appleton, Alexander Oraevsky, Mark A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Scopus citations

Abstract

Because optoacoustic tomography (OAT) can provide functional information based on hemoglobin contrast, it is a promising imaging modality for breast cancer diagnosis. Developing an effective OAT breast imaging system requires balancing multiple design constraints, which can be expensive and time-consuming. Therefore, computer-simulation studies are often conducted to facilitate this task. However, most existing computer-simulation studies of OAT breast imaging employ simple phantoms such as spheres or cylinders that over-simplify the complex anatomical structures in breasts, thus limiting the value of these studies in guiding real-world system design. In this work, we propose a method to generate realistic numerical breast phantoms for OAT research based on clinical magnetic resonance imaging (MRI) data. The phantoms include a skin layer that defines breast-air boundary, major vessel branches that affect light absorption in the breast, and fatty tissue and fibroglandular tissue whose acoustical heterogeneity perturbs acoustic wave propagation. By assigning realistic optical and acoustic parameters to different tissue types, we establish both optic and acoustic breast phantoms, which will be exported into standard data formats for cross-platform usage.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2016
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781628419429
DOIs
StatePublished - 2016
EventPhotons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, United States
Duration: Feb 14 2016Feb 17 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9708
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2016
Country/TerritoryUnited States
CitySan Francisco
Period02/14/1602/17/16

Keywords

  • Optoacoustic tomography
  • breast cancer imaging
  • breast segmentation
  • photoacoustic tomography
  • vessel segmentation

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