Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant

Zaid Muhammad; Phoebe W. Brown; Larema Babazau; Abdulrahman I. Alkhamis; Baba W. Goni; Haruna A. Nggada; Kefas M. Mbaya; Selina Wray; Isa H. Marte; Celeste M. Karch; Louise C. Serpell; Mahmoud B. Maina

doi:10.1016/j.scr.2024.103503

Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant

Zaid Muhammad, Phoebe W. Brown, Larema Babazau, Abdulrahman I. Alkhamis, Baba W. Goni, Haruna A. Nggada, Kefas M. Mbaya, Selina Wray, Isa H. Marte, Celeste M. Karch, Louise C. Serpell, Mahmoud B. Maina

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Abstract

Genetic backgrounds influence cellular phenotypes, drug responses, and health outcomes, yet most human iPSC lines are derived from individuals of European descent, with lines from indigenous Africans particularly scarce. Addressing this gap, we generated iPSCs from dermal fibroblasts of a healthy 60-year-old indigenous Nigerian male of the Babur ethnic group using Sendai virus. The iPSC line displayed a normal karyotype, was characterized for pluripotency markers and differentiated into neural progenitor cells and astrocytes. To enhance African representation in research, this iPSC line will be available to the scientific community, with ongoing efforts focused on creating an open-access African iPSC biobank.

Original language	English
Article number	103503
Journal	Stem Cell Research
Volume	80
DOIs	https://doi.org/10.1016/j.scr.2024.103503
State	Published - Oct 2024

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Muhammad, Z., Brown, P. W., Babazau, L., Alkhamis, A. I., Goni, B. W., Nggada, H. A., Mbaya, K. M., Wray, S., Marte, I. H., Karch, C. M., Serpell, L. C., & Maina, M. B. (2024). Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant. Stem Cell Research, 80, Article 103503. https://doi.org/10.1016/j.scr.2024.103503

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abstract = "Genetic backgrounds influence cellular phenotypes, drug responses, and health outcomes, yet most human iPSC lines are derived from individuals of European descent, with lines from indigenous Africans particularly scarce. Addressing this gap, we generated iPSCs from dermal fibroblasts of a healthy 60-year-old indigenous Nigerian male of the Babur ethnic group using Sendai virus. The iPSC line displayed a normal karyotype, was characterized for pluripotency markers and differentiated into neural progenitor cells and astrocytes. To enhance African representation in research, this iPSC line will be available to the scientific community, with ongoing efforts focused on creating an open-access African iPSC biobank.",

author = "Zaid Muhammad and Brown, {Phoebe W.} and Larema Babazau and Alkhamis, {Abdulrahman I.} and Goni, {Baba W.} and Nggada, {Haruna A.} and Mbaya, {Kefas M.} and Selina Wray and Marte, {Isa H.} and Karch, {Celeste M.} and Serpell, {Louise C.} and Maina, {Mahmoud B.}",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = oct,

doi = "10.1016/j.scr.2024.103503",

language = "English",

volume = "80",

journal = "Stem Cell Research",

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AU - Muhammad, Zaid

AU - Brown, Phoebe W.

AU - Babazau, Larema

AU - Alkhamis, Abdulrahman I.

AU - Goni, Baba W.

AU - Nggada, Haruna A.

AU - Mbaya, Kefas M.

AU - Wray, Selina

AU - Marte, Isa H.

AU - Karch, Celeste M.

AU - Serpell, Louise C.

AU - Maina, Mahmoud B.

PY - 2024/10

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AB - Genetic backgrounds influence cellular phenotypes, drug responses, and health outcomes, yet most human iPSC lines are derived from individuals of European descent, with lines from indigenous Africans particularly scarce. Addressing this gap, we generated iPSCs from dermal fibroblasts of a healthy 60-year-old indigenous Nigerian male of the Babur ethnic group using Sendai virus. The iPSC line displayed a normal karyotype, was characterized for pluripotency markers and differentiated into neural progenitor cells and astrocytes. To enhance African representation in research, this iPSC line will be available to the scientific community, with ongoing efforts focused on creating an open-access African iPSC biobank.

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Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant

Abstract

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