Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

Dominantly Inherited Alzheimer Network (DIAN); Damián Hernández; Stephanie Morgan Schlicht; Jordan Elli Clarke; Maciej Daniszewski; Celeste M. Karch; Sarah Adams; Ricardo Allegri; Aki Araki; Nicolas Barthelemy; Randall Bateman; Jacob Bechara; Tammie Benzinger; Sarah Berman; Courtney Bodge; Sus Brandon; William (Bill) Brooks; Jared Brosch; Jill Buck; Virginia Buckles; Kathleen Carter; Lisa Cash; Charlie Chen; Jasmeer Chhatwal; Patricio Chrem Mendez; Jasmin Chua; Helena Chui; Laura Courtney; Carlos Cruchaga; Gregory Day; Chrismary DeLaCruz; Darcy Denner; Anna Diffenbacher; Aylin Dincer; Tamara Donahue; Jane Douglas; Duc Duong; Noelia Egido; Bianca Esposito; Anne Fagan; Marty Farlow; Becca Feldman; Colleen Fitzpatrick; Shaney Flores; Nick Fox; Erin Franklin; Nelly Friedrichsen; Hisako Fujii; Samantha Gardener; Bernardino Ghetti; Alison Goate; Sarah Goldberg; Jill Goldman; Alyssa Gonzalez; Brian Gordon; Susanne Gr¨aber-Sultan; Neill Graff-Radford; Morgan Graham; Julia Gray; Emily Gremminger; Miguel Grilo; Alex Groves; Christian Haass; Lisa H¨asler; Jason Hassenstab; Cortaiga Hellm; Elizabeth Herries; Laura Hoechst-Swisher; Anna Hofmann; David Holtzman; Russ Hornbeck; Yakushev Igor; Ryoko Ihara; Takeshi Ikeuchi; Snezana Ikonomovic; Kenji Ishii; Clifford Jack; Gina Jerome; Erik Johnson; Mathias Jucker; Celeste Karch; Stephan K¨aser; Kensaku Kasuga; Sarah Keefe; William Klunk; Robert Koeppe; Deb Koudelis; Elke Kuder-Buletta; Christoph Laske; Allan Levey; Johannes Levin; Yan Li; Oscar Lopez; Jacob Marsh; Ralph Martins; Neal Scott Mason; Colin Masters; Kwasi Mawuenyega; Austin McCullough; Eric McDade; Arlene Mejia; Estrella Morenas-Rodriguez; John Morris; James Mountz; Cath Mummery; Neelesh Nadkarni; Akemi Nagamatsu; Katie Neimeyer; Yoshiki Niimi; James Noble; Joanne Norton; Brigitte Nuscher; Ulricke Obermüller; Antoinette O'Connor; Riddhi Patira; Richard Perrin; Lingyan Ping; Oliver Preische; Alan Renton; John Ringman; Stephen Salloway; Peter Schofield; Michio Senda; Nicholas T. Seyfried; Kristine Shady; Hiroyuki Shimada; Wendy Sigurdson; Jennifer Smith; Lori Smith; Beth Snitz; Hamid Sohrabi; Sochenda Stephens; Kevin Taddei; Sarah Thompson; Jonathan V¨oglein; Peter Wang; Qing Wang; Elise Weamer; Chengjie Xiong; Jinbin Xu; Xiong Xu; Alison M. Goate; Alice Pébay

doi:10.1016/j.scr.2024.103495

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

Dominantly Inherited Alzheimer Network (DIAN), Damián Hernández, Stephanie Morgan Schlicht, Jordan Elli Clarke, Maciej Daniszewski, Celeste M. Karch, Sarah Adams, Ricardo Allegri, Aki Araki, Nicolas Barthelemy, Randall Bateman, Jacob Bechara, Tammie Benzinger, Sarah Berman, Courtney Bodge, Sus Brandon, William (Bill) Brooks, Jared Brosch, Jill Buck, Virginia BucklesKathleen Carter, Lisa Cash, Charlie Chen, Jasmeer Chhatwal, Patricio Chrem Mendez, Jasmin Chua, Helena Chui, Laura Courtney, Carlos Cruchaga, Gregory Day, Chrismary DeLaCruz, Darcy Denner, Anna Diffenbacher, Aylin Dincer, Tamara Donahue, Jane Douglas, Duc Duong, Noelia Egido, Bianca Esposito, Anne Fagan, Marty Farlow, Becca Feldman, Colleen Fitzpatrick, Shaney Flores, Nick Fox, Erin Franklin, Nelly Friedrichsen, Hisako Fujii, Samantha Gardener, Bernardino Ghetti, Alison Goate, Sarah Goldberg, Jill Goldman, Alyssa Gonzalez, Brian Gordon, Susanne Gr¨aber-Sultan, Neill Graff-Radford, Morgan Graham, Julia Gray, Emily Gremminger, Miguel Grilo, Alex Groves, Christian Haass, Lisa H¨asler, Jason Hassenstab, Cortaiga Hellm, Elizabeth Herries, Laura Hoechst-Swisher, Anna Hofmann, David Holtzman, Russ Hornbeck, Yakushev Igor, Ryoko Ihara, Takeshi Ikeuchi, Snezana Ikonomovic, Kenji Ishii, Clifford Jack, Gina Jerome, Erik Johnson, Mathias Jucker, Celeste Karch, Stephan K¨aser, Kensaku Kasuga, Sarah Keefe, William Klunk, Robert Koeppe, Deb Koudelis, Elke Kuder-Buletta, Christoph Laske, Allan Levey, Johannes Levin, Yan Li, Oscar Lopez, Jacob Marsh, Ralph Martins, Neal Scott Mason, Colin Masters, Kwasi Mawuenyega, Austin McCullough, Eric McDade, Arlene Mejia, Estrella Morenas-Rodriguez, John Morris, James Mountz, Cath Mummery, Neelesh Nadkarni, Akemi Nagamatsu, Katie Neimeyer, Yoshiki Niimi, James Noble, Joanne Norton, Brigitte Nuscher, Ulricke Obermüller, Antoinette O'Connor, Riddhi Patira, Richard Perrin, Lingyan Ping, Oliver Preische, Alan Renton, John Ringman, Stephen Salloway, Peter Schofield, Michio Senda, Nicholas T. Seyfried, Kristine Shady, Hiroyuki Shimada, Wendy Sigurdson, Jennifer Smith, Lori Smith, Beth Snitz, Hamid Sohrabi, Sochenda Stephens, Kevin Taddei, Sarah Thompson, Jonathan V¨oglein, Peter Wang, Qing Wang, Elise Weamer, Chengjie Xiong, Jinbin Xu, Xiong Xu, Alison M. Goate, Alice Pébay

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Abstract

We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.

Original language	English
Article number	103495
Journal	Stem Cell Research
Volume	79
DOIs	https://doi.org/10.1016/j.scr.2024.103495
State	Published - Sep 2024

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10.1016/j.scr.2024.103495

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Dominantly Inherited Alzheimer Network (DIAN), Hernández, D., Morgan Schlicht, S., Elli Clarke, J., Daniszewski, M., Karch, C. M., Adams, S., Allegri, R., Araki, A., Barthelemy, N., Bateman, R., Bechara, J., Benzinger, T., Berman, S., Bodge, C., Brandon, S., (Bill) Brooks, W., Brosch, J., Buck, J., ... Pébay, A. (2024). Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation. Stem Cell Research, 79, Article 103495. https://doi.org/10.1016/j.scr.2024.103495

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title = "Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation",

abstract = "We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.",

author = "{Dominantly Inherited Alzheimer Network (DIAN)} and Dami{\'a}n Hern{\'a}ndez and {Morgan Schlicht}, Stephanie and {Elli Clarke}, Jordan and Maciej Daniszewski and Karch, {Celeste M.} and Sarah Adams and Ricardo Allegri and Aki Araki and Nicolas Barthelemy and Randall Bateman and Jacob Bechara and Tammie Benzinger and Sarah Berman and Courtney Bodge and Sus Brandon and {(Bill) Brooks}, William and Jared Brosch and Jill Buck and Virginia Buckles and Kathleen Carter and Lisa Cash and Charlie Chen and Jasmeer Chhatwal and {Chrem Mendez}, Patricio and Jasmin Chua and Helena Chui and Laura Courtney and Carlos Cruchaga and Gregory Day and Chrismary DeLaCruz and Darcy Denner and Anna Diffenbacher and Aylin Dincer and Tamara Donahue and Jane Douglas and Duc Duong and Noelia Egido and Bianca Esposito and Anne Fagan and Marty Farlow and Becca Feldman and Colleen Fitzpatrick and Shaney Flores and Nick Fox and Erin Franklin and Nelly Friedrichsen and Hisako Fujii and Samantha Gardener and Bernardino Ghetti and Alison Goate and Sarah Goldberg and Jill Goldman and Alyssa Gonzalez and Brian Gordon and Susanne Gr¨aber-Sultan and Neill Graff-Radford and Morgan Graham and Julia Gray and Emily Gremminger and Miguel Grilo and Alex Groves and Christian Haass and Lisa H¨asler and Jason Hassenstab and Cortaiga Hellm and Elizabeth Herries and Laura Hoechst-Swisher and Anna Hofmann and David Holtzman and Russ Hornbeck and Yakushev Igor and Ryoko Ihara and Takeshi Ikeuchi and Snezana Ikonomovic and Kenji Ishii and Clifford Jack and Gina Jerome and Erik Johnson and Mathias Jucker and Celeste Karch and Stephan K¨aser and Kensaku Kasuga and Sarah Keefe and William Klunk and Robert Koeppe and Deb Koudelis and Elke Kuder-Buletta and Christoph Laske and Allan Levey and Johannes Levin and Yan Li and Oscar Lopez and Jacob Marsh and Ralph Martins and {Scott Mason}, Neal and Colin Masters and Kwasi Mawuenyega and Austin McCullough and Eric McDade and Arlene Mejia and Estrella Morenas-Rodriguez and John Morris and James Mountz and Cath Mummery and Neelesh Nadkarni and Akemi Nagamatsu and Katie Neimeyer and Yoshiki Niimi and James Noble and Joanne Norton and Brigitte Nuscher and Ulricke Oberm{\"u}ller and Antoinette O'Connor and Riddhi Patira and Richard Perrin and Lingyan Ping and Oliver Preische and Alan Renton and John Ringman and Stephen Salloway and Peter Schofield and Michio Senda and Seyfried, {Nicholas T.} and Kristine Shady and Hiroyuki Shimada and Wendy Sigurdson and Jennifer Smith and Lori Smith and Beth Snitz and Hamid Sohrabi and Sochenda Stephens and Kevin Taddei and Sarah Thompson and Jonathan V¨oglein and Peter Wang and Qing Wang and Elise Weamer and Chengjie Xiong and Jinbin Xu and Xiong Xu and Goate, {Alison M.} and Alice P{\'e}bay",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = sep,

doi = "10.1016/j.scr.2024.103495",

language = "English",

volume = "79",

journal = "Stem Cell Research",

issn = "1873-5061",

}

Dominantly Inherited Alzheimer Network (DIAN), Hernández, D, Morgan Schlicht, S, Elli Clarke, J, Daniszewski, M, Karch, CM, Adams, S, Allegri, R, Araki, A, Barthelemy, N, Bateman, R, Bechara, J, Benzinger, T, Berman, S, Bodge, C, Brandon, S, (Bill) Brooks, W, Brosch, J, Buck, J, Buckles, V, Carter, K, Cash, L, Chen, C, Chhatwal, J, Chrem Mendez, P, Chua, J, Chui, H, Courtney, L, Cruchaga, C, Day, G, DeLaCruz, C, Denner, D, Diffenbacher, A, Dincer, A, Donahue, T, Douglas, J, Duong, D, Egido, N, Esposito, B, Fagan, A, Farlow, M, Feldman, B, Fitzpatrick, C, Flores, S, Fox, N, Franklin, E, Friedrichsen, N, Fujii, H, Gardener, S, Ghetti, B, Goate, A, Goldberg, S, Goldman, J, Gonzalez, A, Gordon, B, Gr¨aber-Sultan, S, Graff-Radford, N, Graham, M, Gray, J, Gremminger, E, Grilo, M, Groves, A, Haass, C, H¨asler, L, Hassenstab, J, Hellm, C, Herries, E, Hoechst-Swisher, L, Hofmann, A, Holtzman, D, Hornbeck, R, Igor, Y, Ihara, R, Ikeuchi, T, Ikonomovic, S, Ishii, K, Jack, C, Jerome, G, Johnson, E, Jucker, M, Karch, C, K¨aser, S, Kasuga, K, Keefe, S, Klunk, W, Koeppe, R, Koudelis, D, Kuder-Buletta, E, Laske, C, Levey, A, Levin, J, Li, Y, Lopez, O, Marsh, J, Martins, R, Scott Mason, N, Masters, C, Mawuenyega, K, McCullough, A, McDade, E, Mejia, A, Morenas-Rodriguez, E, Morris, J, Mountz, J, Mummery, C, Nadkarni, N, Nagamatsu, A, Neimeyer, K, Niimi, Y, Noble, J, Norton, J, Nuscher, B, Obermüller, U, O'Connor, A, Patira, R, Perrin, R, Ping, L, Preische, O, Renton, A, Ringman, J, Salloway, S, Schofield, P, Senda, M, Seyfried, NT, Shady, K, Shimada, H, Sigurdson, W, Smith, J, Smith, L, Snitz, B, Sohrabi, H, Stephens, S, Taddei, K, Thompson, S, V¨oglein, J, Wang, P, Wang, Q, Weamer, E, Xiong, C, Xu, J, Xu, X, Goate, AM & Pébay, A 2024, 'Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation', Stem Cell Research, vol. 79, 103495. https://doi.org/10.1016/j.scr.2024.103495

TY - JOUR

T1 - Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

AU - Dominantly Inherited Alzheimer Network (DIAN)

AU - Hernández, Damián

AU - Morgan Schlicht, Stephanie

AU - Elli Clarke, Jordan

AU - Daniszewski, Maciej

AU - Karch, Celeste M.

AU - Adams, Sarah

AU - Allegri, Ricardo

AU - Araki, Aki

AU - Barthelemy, Nicolas

AU - Bateman, Randall

AU - Bechara, Jacob

AU - Benzinger, Tammie

AU - Berman, Sarah

AU - Bodge, Courtney

AU - Brandon, Sus

AU - (Bill) Brooks, William

AU - Brosch, Jared

AU - Buck, Jill

AU - Buckles, Virginia

AU - Carter, Kathleen

AU - Cash, Lisa

AU - Chen, Charlie

AU - Chhatwal, Jasmeer

AU - Chrem Mendez, Patricio

AU - Chua, Jasmin

AU - Chui, Helena

AU - Courtney, Laura

AU - Cruchaga, Carlos

AU - Day, Gregory

AU - DeLaCruz, Chrismary

AU - Denner, Darcy

AU - Diffenbacher, Anna

AU - Dincer, Aylin

AU - Donahue, Tamara

AU - Douglas, Jane

AU - Duong, Duc

AU - Egido, Noelia

AU - Esposito, Bianca

AU - Fagan, Anne

AU - Farlow, Marty

AU - Feldman, Becca

AU - Fitzpatrick, Colleen

AU - Flores, Shaney

AU - Fox, Nick

AU - Franklin, Erin

AU - Friedrichsen, Nelly

AU - Fujii, Hisako

AU - Gardener, Samantha

AU - Ghetti, Bernardino

AU - Goate, Alison

AU - Goldberg, Sarah

AU - Goldman, Jill

AU - Gonzalez, Alyssa

AU - Gordon, Brian

AU - Gr¨aber-Sultan, Susanne

AU - Graff-Radford, Neill

AU - Graham, Morgan

AU - Gray, Julia

AU - Gremminger, Emily

AU - Grilo, Miguel

AU - Groves, Alex

AU - Haass, Christian

AU - H¨asler, Lisa

AU - Hassenstab, Jason

AU - Hellm, Cortaiga

AU - Herries, Elizabeth

AU - Hoechst-Swisher, Laura

AU - Hofmann, Anna

AU - Holtzman, David

AU - Hornbeck, Russ

AU - Igor, Yakushev

AU - Ihara, Ryoko

AU - Ikeuchi, Takeshi

AU - Ikonomovic, Snezana

AU - Ishii, Kenji

AU - Jack, Clifford

AU - Jerome, Gina

AU - Johnson, Erik

AU - Jucker, Mathias

AU - Karch, Celeste

AU - K¨aser, Stephan

AU - Kasuga, Kensaku

AU - Keefe, Sarah

AU - Klunk, William

AU - Koeppe, Robert

AU - Koudelis, Deb

AU - Kuder-Buletta, Elke

AU - Laske, Christoph

AU - Levey, Allan

AU - Levin, Johannes

AU - Li, Yan

AU - Lopez, Oscar

AU - Marsh, Jacob

AU - Martins, Ralph

AU - Scott Mason, Neal

AU - Masters, Colin

AU - Mawuenyega, Kwasi

AU - McCullough, Austin

AU - McDade, Eric

AU - Mejia, Arlene

AU - Morenas-Rodriguez, Estrella

AU - Morris, John

AU - Mountz, James

AU - Mummery, Cath

AU - Nadkarni, Neelesh

AU - Nagamatsu, Akemi

AU - Neimeyer, Katie

AU - Niimi, Yoshiki

AU - Noble, James

AU - Norton, Joanne

AU - Nuscher, Brigitte

AU - Obermüller, Ulricke

AU - O'Connor, Antoinette

AU - Patira, Riddhi

AU - Perrin, Richard

AU - Ping, Lingyan

AU - Preische, Oliver

AU - Renton, Alan

AU - Ringman, John

AU - Salloway, Stephen

AU - Schofield, Peter

AU - Senda, Michio

AU - Seyfried, Nicholas T.

AU - Shady, Kristine

AU - Shimada, Hiroyuki

AU - Sigurdson, Wendy

AU - Smith, Jennifer

AU - Smith, Lori

AU - Snitz, Beth

AU - Sohrabi, Hamid

AU - Stephens, Sochenda

AU - Taddei, Kevin

AU - Thompson, Sarah

AU - V¨oglein, Jonathan

AU - Wang, Peter

AU - Wang, Qing

AU - Weamer, Elise

AU - Xiong, Chengjie

AU - Xu, Jinbin

AU - Xu, Xiong

AU - Goate, Alison M.

AU - Pébay, Alice

PY - 2024/9

Y1 - 2024/9

N2 - We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.

AB - We report the generation of a gene-edited human induced pluripotent stem cell (iPSC) line from an Alzheimer's disease patient-derived iPSC line harbouring the PSEN1 H163R mutation. This line demonstrates pluripotent stem cell morphology, expression of pluripotency markers, and maintains a normal karyotype.

UR - http://www.scopus.com/inward/record.url?scp=85199722897&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2024.103495

DO - 10.1016/j.scr.2024.103495

M3 - Article

C2 - 39079290

AN - SCOPUS:85199722897

SN - 1873-5061

VL - 79

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 103495

ER -

Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the PSEN1 H163R mutation

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