Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the London mutation in APP (V717I)

Dominantly Inherited Alzheimer Network (DIAN)

Research output: Contribution to journalArticlepeer-review

Abstract

We report the genome-editing of an existing iPSC line carrying the London mutation in APP (V717I) into an iPSC line in which the pathogenic mutation was corrected. The resulting isogenic iPSC line maintained pluripotent stem cell morphology, a normal karyotype, expression of pluripotency markers and the ability to differentiate into the three germ-layers in vitro.

Original languageEnglish
Article number102373
JournalStem Cell Research
Volume53
DOIs
StatePublished - May 2021

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