The generation of specialized cell types during sporulation in Bacillus subtilis occurs in conjunction with formation of an asymmetrically positioned septum that partitions the sporangium into dissimilar-sized progeny. Differentiation is governed by the activation in the smaller cell of transcription factor σF, which sets in motion a chain of events leading to the cell-specific appearance of three additional RNA polymerase sigma factors. Understanding the establishment of cell type requires elucidation of the role of asymmetric septation in the cell-specific activation of σF and of the mechanisms that govern the placement of the sporulation septum.

Original languageEnglish
Pages (from-to)335-345
Number of pages11
JournalSeminars in Developmental Biology
Issue number5
StatePublished - 1995


  • asymmetry
  • Bacillus subtilis
  • cell division
  • development
  • sporulation


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