Generating protective immunity against genital herpes

Haina Shin, Akiko Iwasaki

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Genital herpes is an incurable, chronic disease that affects millions of people worldwide. Not only does genital herpes cause painful, recurrent symptoms, it is also a significant risk factor for the acquisition of other sexually transmitted infections such as HIV-1. Antiviral drugs are used to treat herpes simplex virus (HSV) infection, but they cannot stop viral shedding and transmission. Thus, developing a vaccine that can prevent or clear infection will be crucial in limiting the spread of disease. In this review we outline recent studies that improve our understanding of host responses against HSV infection, discuss past clinical vaccine trials, and highlight new strategies for vaccine design against genital herpes.

Original languageEnglish
Pages (from-to)487-494
Number of pages8
JournalTrends in Immunology
Volume34
Issue number10
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

Keywords

  • Antibodies
  • Cell migration
  • Female genital tract
  • Memory T cells
  • Protective immunity
  • Vaccines

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