Generalized gap model for bacterial artificial chromosome clone fingerprint mapping and shotgun sequencing

Michael C. Wendl, Robert H. Waterston

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

We develop an extension to the Lander-Waterman theory for characterizing gaps in bacterial artificial chromosome fingerprint mapping and shotgun sequencing projects. It supports a larger set of descriptive statistics and is applicable to a wider range of project parameters. We show that previous assertions regarding inconsistency of the Lander-Waterman theory at higher coverages are incorrect and that another well-known but ostensibly different model is in fact the same. The apparent paradox of infinite island lengths is resolved. Several applications are shown, including evolution of the probability density function, calculation of closure probabilities, and development of a probabilistic method for computing stopping points in bacterial artificial chromosome shotgun sequencing.

Original languageEnglish
Pages (from-to)1943-1949
Number of pages7
JournalGenome research
Volume12
Issue number12
DOIs
StatePublished - Dec 1 2002

Fingerprint Dive into the research topics of 'Generalized gap model for bacterial artificial chromosome clone fingerprint mapping and shotgun sequencing'. Together they form a unique fingerprint.

Cite this