Generalized anxiety disorder in late life: Lifetime course and comorbidity with major depressive disorder

Eric J. Lenze, Benoit H. Mulsant, Jan Mohlman, M. Katherine Shear, Mary Amanda Dew, Richard Schulz, Mark D. Miller, Barbara Tracey, Charles F. Reynolds

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Objective: Generalized anxiety disorder (GAD) in elderly persons is highly prevalent, but little is known about its course, age at onset, and relationship to comorbid major depressive disorder (MDD). The authors assessed the course and comorbidity of late-life GAD and MDD. Methods: Authors assessed elderly subjects in anxiety or depression intervention studies who had a lifetime history of GAD, with current MDD (N = 57) or without (N = 46). Subjects' lifetime course of illness was charted retrospectively. Results: The 103 subjects had a mean age of 74.1 years, and a mean age at onset of GAD of 48.8 years; 46% were late-onset. GAD episodes were chronic, and 36% were longer than 10 years. Of the comorbid GAD-MDD patients, most had different times of onset and/or offset of the disorders; typically, GAD preceded MDD. Conclusions: Elderly subjects with GAD tended to have chronic symptoms lasting years-to-decades, without interruption, and many have late onset. Elderly persons with lifetime GAD and MDD tend to have different onset and offset of the two disorders. Findings characterize late-life GAD as a chronic disorder distinct from MDD.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalAmerican Journal of Geriatric Psychiatry
Issue number1
StatePublished - Jan 2005


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