TY - CHAP
T1 - General properties of dendritic cell populations in cancer
AU - Daniel, Benjamin J.
AU - Jeansonne, Duane P.
AU - Thibodeaux, Suzanne R.
AU - Curiel, Tyler J.
PY - 2009
Y1 - 2009
N2 - Various, distinct populations of dendritic cells (DC) populate different normal, quiescent tissues in differing amounts, where they subserve a variety of functions generally for the benefit of the host. In cancers, the types, relative proportions, and functions of DC are altered, often to the detriment of the host. This chapter reviews the general issues related to imbalanced DC populations and their causes and dysfunctional consequences in the tumor microenvironment. Potential applications of this knowledge to novel anti-cancer immunotherapy strategies are outlined. Human and mouse disease models suitable for the study of tumor microenvironmental DC are discussed.
AB - Various, distinct populations of dendritic cells (DC) populate different normal, quiescent tissues in differing amounts, where they subserve a variety of functions generally for the benefit of the host. In cancers, the types, relative proportions, and functions of DC are altered, often to the detriment of the host. This chapter reviews the general issues related to imbalanced DC populations and their causes and dysfunctional consequences in the tumor microenvironment. Potential applications of this knowledge to novel anti-cancer immunotherapy strategies are outlined. Human and mouse disease models suitable for the study of tumor microenvironmental DC are discussed.
UR - http://www.scopus.com/inward/record.url?scp=84900208431&partnerID=8YFLogxK
U2 - 10.1007/978-0-387-88611-4_5
DO - 10.1007/978-0-387-88611-4_5
M3 - Chapter
AN - SCOPUS:84900208431
SN - 9780387886107
SP - 77
EP - 87
BT - Dendritic Cells in Cancer
PB - Springer US
ER -