General population job exposure matrix applied to a pooled study of prevalent carpal tunnel syndrome

Ann Marie Dale, Angelique Zeringue, Carisa Harris-Adamson, David Rempel, Stephen Bao, Matthew S. Thiese, Linda Merlino, Susan Burt, Jay Kapellusch, Arun Garg, Fred Gerr, Kurt T. Hegmann, Ellen A. Eisen, Bradley Evanoff

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A job exposure matrix may be useful for the study of biomechanical workplace risk factors when individual-level exposure data are unavailable. We used job title-based exposure data from a public data source to construct a job exposure matrix and test exposure-response relationships with prevalent carpal tunnel syndrome (CTS). Exposures of repetitive motion and force from the Occupational Information Network were assigned to 3,452 active workers from several industries, enrolled between 2001 and 2008 from 6 studies. Repetitive motion and force exposures were combined into high/high, high/low, and low/low exposure groupings in each of 4 multivariable logistic regression models, adjusted for personal factors. Although force measures alone were not independent predictors of CTS in these data, strong associations between combined physical exposures of force and repetition and CTS were observed in all models. Consistent with previous literature, this report shows that workers with high force/high repetition jobs had the highest prevalence of CTS (odds ratio = 2.14-2.95) followed by intermediate values (odds ratio = 1.09-2.27) in mixed exposed jobs relative to the lowest exposed workers. This study supports the use of a general population job exposure matrix to estimate workplace physical exposures in epidemiologic studies of musculoskeletal disorders when measures of individual exposures are unavailable.

Original languageEnglish
Pages (from-to)431-439
Number of pages9
JournalAmerican journal of epidemiology
Issue number6
StatePublished - Dec 8 2015


  • O∗NET
  • cross-sectional study
  • ergonomics
  • general worker population
  • job exposure matrix
  • musculoskeletal disorders
  • pooled study
  • upper extremity


Dive into the research topics of 'General population job exposure matrix applied to a pooled study of prevalent carpal tunnel syndrome'. Together they form a unique fingerprint.

Cite this