TY - JOUR
T1 - General Anesthesia During the Third Trimester
T2 - Any Link to Neurocognitive Outcomes?
AU - De Tina, Annemaria
AU - Palanisamy, Arvind
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Rodent studies on the effect of general anesthesia during the third trimester on neurocognitive outcomes are mixed, but primate studies suggest that a clinically relevant exposure to anesthetic agents during the third trimester can trigger neuronal and glial cell death. Human studies are conflicting and the evidence is weak. This is an up-to-date review of the literature on the neurodevelopmental effects of anesthetic agents administered during the third trimester. Early brain development and critical periods of neurodevelopment as it relates to neurotoxicity are highlighted. Rodent, nonhuman primate, and population studies are discussed and placed in the context of clinical practice.
AB - Rodent studies on the effect of general anesthesia during the third trimester on neurocognitive outcomes are mixed, but primate studies suggest that a clinically relevant exposure to anesthetic agents during the third trimester can trigger neuronal and glial cell death. Human studies are conflicting and the evidence is weak. This is an up-to-date review of the literature on the neurodevelopmental effects of anesthetic agents administered during the third trimester. Early brain development and critical periods of neurodevelopment as it relates to neurotoxicity are highlighted. Rodent, nonhuman primate, and population studies are discussed and placed in the context of clinical practice.
KW - Developmental neurotoxicity of anesthetics
KW - Fetal neurodevelopment
KW - Fetal surgery
KW - Maternal anesthesia
KW - Prenatal exposure
KW - Third trimester anesthesia
UR - http://www.scopus.com/inward/record.url?scp=85009170417&partnerID=8YFLogxK
U2 - 10.1016/j.anclin.2016.09.007
DO - 10.1016/j.anclin.2016.09.007
M3 - Review article
C2 - 28131121
AN - SCOPUS:85009170417
SN - 1932-2275
VL - 35
SP - 69
EP - 80
JO - Anesthesiology Clinics
JF - Anesthesiology Clinics
IS - 1
ER -