General and efficient synthetic approach to novel tricyclic spiroketones

Guo Hua Chu; Bertrand Le Bourdonnec; Minghua Gu; Christopher T. Saeui; Roland E. Dolle

doi:10.1016/j.tet.2009.04.094

General and efficient synthetic approach to novel tricyclic spiroketones

Guo Hua Chu, Bertrand Le Bourdonnec, Minghua Gu, Christopher T. Saeui, Roland E. Dolle

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A general and efficient synthetic approach to tricyclic spiroketones of interest as useful scaffolds in drug discovery was developed. Starting from commercially available benzyl 4-oxo-1-piperidinecarboxylate (5), spirocyclic tetralone 4, spirocyclic indanone 14, and spirocyclic benzocycloheptanone 15 were synthesized via six reaction steps in excellent overall yield.

Original language	English
Pages (from-to)	5161-5167
Number of pages	7
Journal	Tetrahedron
Volume	65
Issue number	27
DOIs	https://doi.org/10.1016/j.tet.2009.04.094
State	Published - Jul 4 2009

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10.1016/j.tet.2009.04.094

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title = "General and efficient synthetic approach to novel tricyclic spiroketones",

abstract = "A general and efficient synthetic approach to tricyclic spiroketones of interest as useful scaffolds in drug discovery was developed. Starting from commercially available benzyl 4-oxo-1-piperidinecarboxylate (5), spirocyclic tetralone 4, spirocyclic indanone 14, and spirocyclic benzocycloheptanone 15 were synthesized via six reaction steps in excellent overall yield.",

author = "Chu, {Guo Hua} and {Le Bourdonnec}, Bertrand and Minghua Gu and Saeui, {Christopher T.} and Dolle, {Roland E.}",

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AU - Chu, Guo Hua

AU - Le Bourdonnec, Bertrand

AU - Gu, Minghua

AU - Saeui, Christopher T.

AU - Dolle, Roland E.

PY - 2009/7/4

Y1 - 2009/7/4

N2 - A general and efficient synthetic approach to tricyclic spiroketones of interest as useful scaffolds in drug discovery was developed. Starting from commercially available benzyl 4-oxo-1-piperidinecarboxylate (5), spirocyclic tetralone 4, spirocyclic indanone 14, and spirocyclic benzocycloheptanone 15 were synthesized via six reaction steps in excellent overall yield.

AB - A general and efficient synthetic approach to tricyclic spiroketones of interest as useful scaffolds in drug discovery was developed. Starting from commercially available benzyl 4-oxo-1-piperidinecarboxylate (5), spirocyclic tetralone 4, spirocyclic indanone 14, and spirocyclic benzocycloheptanone 15 were synthesized via six reaction steps in excellent overall yield.

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DO - 10.1016/j.tet.2009.04.094

M3 - Article

AN - SCOPUS:66149138834

SN - 0040-4020

VL - 65

SP - 5161

EP - 5167

JO - Tetrahedron

JF - Tetrahedron

IS - 27

ER -

General and efficient synthetic approach to novel tricyclic spiroketones

Abstract

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