Gene therapy targeted by ionizing radiation

Ralph R. Weichselbaum; Dennis E. Hallahan; Vikas P. Sukhatme; Donald W. Kufe

doi:10.1016/0360-3016(92)91075-X

Gene therapy targeted by ionizing radiation

Ralph R. Weichselbaum, Dennis E. Hallahan, Vikas P. Sukhatme, Donald W. Kufe

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Gene therapy used for the treatment of neoplastic diseases is not well localized. Ionizing radiation can be used to activate the transcription of exogenous genes that encode cytotoxic proteins. This may be accomplished through the use of radiation responsive elements distal to the transcription start site of such genes. We discuss this concept and describe a technique which can be used to amplify the signal initiated by localized radiation therapy. These techniques may be used to target gene therapy during the treatment of human neoplasms.

Original language	English
Pages (from-to)	565-567
Number of pages	3
Journal	International journal of radiation oncology, biology, physics
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/0360-3016(92)91075-X
State	Published - 1992

Keywords

Gene therapy
Transcription
X-rays

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10.1016/0360-3016(92)91075-X

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@article{881d102e127a4b488bce600fbba2bf1e,

title = "Gene therapy targeted by ionizing radiation",

abstract = "Gene therapy used for the treatment of neoplastic diseases is not well localized. Ionizing radiation can be used to activate the transcription of exogenous genes that encode cytotoxic proteins. This may be accomplished through the use of radiation responsive elements distal to the transcription start site of such genes. We discuss this concept and describe a technique which can be used to amplify the signal initiated by localized radiation therapy. These techniques may be used to target gene therapy during the treatment of human neoplasms.",

keywords = "Gene therapy, Transcription, X-rays",

author = "Weichselbaum, {Ralph R.} and Hallahan, {Dennis E.} and Sukhatme, {Vikas P.} and Kufe, {Donald W.}",

note = "Funding Information: Reprint request to: Ralph R. Weichselbaum, M.D., University of Chicago, Radiation and Cellular Oncology Department, 584 1 South Maryland, Box 442, Chicago, IL 60637. Acknowledgements-This work has been funded by: Center for Radiation Therapy, Chicago Tumor Institute, NIH Grants #CA-",

year = "1992",

doi = "10.1016/0360-3016(92)91075-X",

language = "English",

volume = "24",

pages = "565--567",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

number = "3",

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TY - JOUR

T1 - Gene therapy targeted by ionizing radiation

AU - Weichselbaum, Ralph R.

AU - Hallahan, Dennis E.

AU - Sukhatme, Vikas P.

AU - Kufe, Donald W.

N1 - Funding Information: Reprint request to: Ralph R. Weichselbaum, M.D., University of Chicago, Radiation and Cellular Oncology Department, 584 1 South Maryland, Box 442, Chicago, IL 60637. Acknowledgements-This work has been funded by: Center for Radiation Therapy, Chicago Tumor Institute, NIH Grants #CA-

PY - 1992

Y1 - 1992

N2 - Gene therapy used for the treatment of neoplastic diseases is not well localized. Ionizing radiation can be used to activate the transcription of exogenous genes that encode cytotoxic proteins. This may be accomplished through the use of radiation responsive elements distal to the transcription start site of such genes. We discuss this concept and describe a technique which can be used to amplify the signal initiated by localized radiation therapy. These techniques may be used to target gene therapy during the treatment of human neoplasms.

AB - Gene therapy used for the treatment of neoplastic diseases is not well localized. Ionizing radiation can be used to activate the transcription of exogenous genes that encode cytotoxic proteins. This may be accomplished through the use of radiation responsive elements distal to the transcription start site of such genes. We discuss this concept and describe a technique which can be used to amplify the signal initiated by localized radiation therapy. These techniques may be used to target gene therapy during the treatment of human neoplasms.

KW - Gene therapy

KW - Transcription

KW - X-rays

UR - http://www.scopus.com/inward/record.url?scp=0026687717&partnerID=8YFLogxK

U2 - 10.1016/0360-3016(92)91075-X

DO - 10.1016/0360-3016(92)91075-X

M3 - Article

C2 - 1399745

AN - SCOPUS:0026687717

SN - 0360-3016

VL - 24

SP - 565

EP - 567

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 3

ER -

Gene therapy targeted by ionizing radiation

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Keywords

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