Gene therapy for lung transplantation

Samer A. Kanaan, Benjamin D. Kozower, G. Alexander Patterson, Stephen D. Cassivi

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The results of lung transplantation have improved for the treatment of many endstage pulmonary diseases. However, they continue to lag behind other solid organ transplants. The 1-, 2-, and 5-year survival for lung transplantation are 70, 60, and 46%, respectively (1). The major obstacle to better long-term survival is bronchiolitis obliterans or chronic rejection. Ischemia reperfusion injury and acute rejection are also associated with significant morbidity and mortality and are risk factors for bronchiolitis obliterans. The treatment of these acute lung injuries remains imprecise and has done little to improve long-term outcome. Gene therapy strategies aimed at prevention and management of ischemia reperfusion injury and acute rejection may reduce chronic rejection and ultimately improve long-term survival.

Original languageEnglish
Title of host publicationGene Therapy in Lung Disease
PublisherCRC Press
Pages457-473
Number of pages17
ISBN (Electronic)9780824743635
ISBN (Print)9780824708207
StatePublished - Jan 1 2002

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    Kanaan, S. A., Kozower, B. D., Alexander Patterson, G., & Cassivi, S. D. (2002). Gene therapy for lung transplantation. In Gene Therapy in Lung Disease (pp. 457-473). CRC Press.