Gene therapy ameliorates spontaneous seizures associated with cortical neuron loss in a Cln2^R207X mouse model

Keyphrases

• Mouse Model 100%
• Gene Therapy 100%
• Spinal Cord 100%
• Neuron Loss 100%
• Pathological Changes 100%
• CLN2 Disease 100%
• Neuronal Ceroid Lipofuscinosis 100%
• Cortical Neurons 100%
• Spontaneous Seizures 100%
• Astrogliosis 50%
• Microglial Activation 50%
• Pathophysiology 50%
• Clinically Significant 50%
• Adenovirus 50%
• Therapeutic Intervention 50%
• Cortex 50%
• Pathogenic mutations 50%
• Seizure 50%
• Histological Analysis 50%
• Disease-modifying Therapy 50%
• Electroencephalography 50%
• Preclinical Efficacy 50%
• Human Patients 50%
• Neuron Population 50%
• Thalamocortical System 50%
• Interneuron 50%
• Virus Serotype 50%
• Seizure Phenotypes 50%
• Clinically Meaningful Outcomes 50%
• Gait Phenotypes 50%
• Epileptiform Abnormalities 50%
• Neonatal Administration 50%
• Model of Others 50%

Medicine and Dentistry

• Epileptic Seizure 100%
• Gene Therapy 100%
• Disease 50%
• Astrocytosis 25%
• Pathophysiology 25%
• Lifespan 25%
• Disease Modifying Therapy 25%
• Adeno-Associated Virus 25%
• Thalamus 25%
• Serotype 25%
• Infantile Neuronal Ceroid Lipofuscinosis 25%
• Batten Disease 25%
• Interneuron 25%