Gene expression profiling: Monitoring transcription and translation products using DNA microarrays and proteomics

Julio E. Celis, Mogens Kruhøffer, Irina Gromova, Casper Frederiksen, Morten Østergaard, Thomas Thykjaer, Pavel Gromov, Jinsheng Yu, Hildur Pálsdóttir, Nils Magnusson, Torben F. Ørntoft

Research output: Contribution to journalReview articlepeer-review

258 Scopus citations

Abstract

Novel and powerful technologies such as DNA microarrays and proteomics have made possible the analysis of the expression levels of multiple genes simultaneously both in health and disease. In combination, these technologies promise to revolutionize biology, in particular in the area of molecular medicine as they are expected to reveal gene regulation events involved in disease progression as well as to pinpoint potential targets for drug discovery and diagnostics. Here, we review the current status of these technologies and highlight some studies in which they have been applied in concert to the analysis of biopsy specimens. (C) 2000 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)2-16
Number of pages15
JournalFEBS Letters
Volume480
Issue number1
DOIs
StatePublished - Aug 25 2000

Keywords

  • Bladder cancer
  • Gene expression profile
  • Immunohistochemistry
  • Microarray
  • Proteome
  • Two-dimensional gel electrophoresis

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