Gene expression profiling in diffuse large B-cell lymphona

Daniel Morgensztern; Mike G. Martin; Izidore S. Lossos

doi:10.1080/10428190601186176

Gene expression profiling in diffuse large B-cell lymphona

Daniel Morgensztern, Mike G. Martin, Izidore S. Lossos

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Diffuse Large B cell lymphoma (DLBCL) is characterized by a markedly heterogeneous clinical course and response to therapy that is not appreciated with standard histopathologic and immunophenotypic evaluations. Analysis of global gene expression using DNA microarrays has the potential to improve the classification of lymphomas. Molecular profiling may allow the description of specific disease subtypes with similar clinical behavior and outcome. In addition, gene expression profiling has led to the discovery of new putative genes and a better understanding of aberrant signaling pathways. These insights may lead to the discovery of new targeted therapies. This review describes the progress that has been made in our understanding of DLBCL as a result of gene expression profiling.

Original language	English
Pages (from-to)	669-682
Number of pages	14
Journal	Leukemia and Lymphoma
Volume	48
Issue number	4
DOIs	https://doi.org/10.1080/10428190601186176
State	Published - Apr 2007

Keywords

BCL-6
DNA arrays
Diffuse large cell lymphoma
HGAL
Lymphoma
Post-transformation diffuse large cell lymphoma

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10.1080/10428190601186176

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title = "Gene expression profiling in diffuse large B-cell lymphona",

abstract = "Diffuse Large B cell lymphoma (DLBCL) is characterized by a markedly heterogeneous clinical course and response to therapy that is not appreciated with standard histopathologic and immunophenotypic evaluations. Analysis of global gene expression using DNA microarrays has the potential to improve the classification of lymphomas. Molecular profiling may allow the description of specific disease subtypes with similar clinical behavior and outcome. In addition, gene expression profiling has led to the discovery of new putative genes and a better understanding of aberrant signaling pathways. These insights may lead to the discovery of new targeted therapies. This review describes the progress that has been made in our understanding of DLBCL as a result of gene expression profiling.",

keywords = "BCL-6, DNA arrays, Diffuse large cell lymphoma, HGAL, Lymphoma, Post-transformation diffuse large cell lymphoma",

author = "Daniel Morgensztern and Martin, {Mike G.} and Lossos, {Izidore S.}",

note = "Funding Information: ISL is supported by RO1 CA109335 from the United States Public Health Service – National Institutes of Health and Dwoskin Family Foundation.",

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AU - Morgensztern, Daniel

AU - Martin, Mike G.

AU - Lossos, Izidore S.

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AB - Diffuse Large B cell lymphoma (DLBCL) is characterized by a markedly heterogeneous clinical course and response to therapy that is not appreciated with standard histopathologic and immunophenotypic evaluations. Analysis of global gene expression using DNA microarrays has the potential to improve the classification of lymphomas. Molecular profiling may allow the description of specific disease subtypes with similar clinical behavior and outcome. In addition, gene expression profiling has led to the discovery of new putative genes and a better understanding of aberrant signaling pathways. These insights may lead to the discovery of new targeted therapies. This review describes the progress that has been made in our understanding of DLBCL as a result of gene expression profiling.

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KW - HGAL

KW - Lymphoma

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Gene expression profiling in diffuse large B-cell lymphona

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