@article{05b1373da6fa482ea85d5c9f8884dd0b,
title = "Gene expression of type II collagens in chondro-osteophytes in experimental osteoarthritis",
abstract = "The formation of chondro-osteophytes in osteoarthritic joints is a unique example of adult neochondrogenesis that bears some similarities to growth plate elongation and fracture callus formation. This study uses in situ hybridization histochemistry to define the molecular phenotype of cells in active chondro-osteophytes. Chondro-osteophytes are composed of fibrocytes and osteoblasts that express type I procollagen mRNA, mesenchymal prechondrocytes that express type IIA procollagen mRNA, and maturing chondrocytes that express type IIB procollagen mRNA. Based on the spatial pattern of gene expression and cytomorphology, the neochondrogenesis associated with chondro-osteophyte formation closely resembles that of healing fracture callus.",
keywords = "alternative splicing, in situ hybridization histochemistry, osteophytes, type II collagen",
author = "Matyas, {J. R.} and Sandell, {L. J.} and Adams, {M. E.}",
note = "Funding Information: We acknowledge the support of The Arthritis Society, The NIH, and The Department of Veteran's Affairs. Funding Information: It seems likely that both mechanical \[4, 6\] and humoral \[10,1 1\] factors are involved in stimulating the formation of chondro-osteophytes, though the exact functional significance of chondro-osteophyte growth remains unclear. There is, however, direct evidence that chondro-oteophytes help stabilize osteoarthritic joints \[12\]N. otwith-standing uncertainties of how and why they form, chondro-osteophytes are a curious example of new cartilage development in osteoarthritic Address correspondence to: John Robert Matyas, Ph.D. Assistant Professor, Departments of Anatomy and Pathology, 3330 Hospital Drive N.W. Calgary, AB T2N 4N1 Canada. Submitted 19 April 1996; accepted 1 July 1996. This study was supported by: The Medical Research Council of Canada, the NIH (R0136994, LJS), and the Department of Veteran's Affairs (LJS). Drs Matyas and Adams receive support from The Arthritis Society.",
year = "1997",
doi = "10.1016/S1063-4584(97)80003-9",
language = "English",
volume = "5",
pages = "99--105",
journal = "Osteoarthritis and Cartilage",
issn = "1063-4584",
number = "2",
}