TY - JOUR
T1 - Gender differences in cancer of the larynx
AU - Kokoska, Mimi S.
AU - Piccirillo, Jay F.
AU - Haughey, Bruce H.
N1 - Funding Information:
Kokoska Mimi S. MD Piccirillo Jay F. MD Haughey Bruce H. MB, ChB St Louis, Missouri Reprints — Mimi S. Kokoska, MD, Dept of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, 517 S Euclid Ave, Box 8115, St Louis, MO 63110 From the Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri. Dr Piccirillo is a recipient of the American Cancer Society Junior Clinical Research Award (JCRA No. 1). 6 1995 104 6 419 424 © 1995 SAGE Publications 1995 SAGE Publications Gender differences in the incidence and mortality rates for cancers of the lung, colon, and larynx have previously been noted. The goal of this project was to identify gender differences in prognostic variables for survival and recurrence for patients with cancer of the larynx. The medical records of 193 patients with cancer of the larynx treated initially between 1973 and 1985 were examined retrospectively. A total of 151 men and 42 women were included. A majority of men developed glottic cancers, whereas a majority of women developed supraglottic cancers. Age was prognostically important for both genders; however, comorbidity, symptom severity, anatomic subsite, and TNM stage all had different impacts on survival and recurrence in men and women. No gender difference in initial treatment was found. This study suggests that when designing and analyzing the results from clinical studies of cancer of the larynx, it is important to employ stratification based on gender. comorbidity gender head and neck cancer prognosis
PY - 1995/6
Y1 - 1995/6
N2 - Gender differences in the incidence and mortality rates for cancers of the lung, colon, and larynx have previously been noted. The goal of this project was to identify gender differences in prognostic variables for survival and recurrence for patients with cancer of the larynx. The medical records of 193 patients with cancer of the larynx treated initially between 1973 and 1985 were examined retrospectively. A total of 151 men and 42 women were included. A majority of men developed glottic cancers, whereas a majority of women developed supraglottic cancers. Age was prognostically important for both genders; however, comorbidity, symptom severity, anatomic subsite, and TNM stage all had different impacts on survival and recurrence in men and women. No gender difference in initial treatment was found. This study suggests that when designing and analyzing the results from clinical studies of cancer of the larynx, it is important to employ stratification based on gender.
AB - Gender differences in the incidence and mortality rates for cancers of the lung, colon, and larynx have previously been noted. The goal of this project was to identify gender differences in prognostic variables for survival and recurrence for patients with cancer of the larynx. The medical records of 193 patients with cancer of the larynx treated initially between 1973 and 1985 were examined retrospectively. A total of 151 men and 42 women were included. A majority of men developed glottic cancers, whereas a majority of women developed supraglottic cancers. Age was prognostically important for both genders; however, comorbidity, symptom severity, anatomic subsite, and TNM stage all had different impacts on survival and recurrence in men and women. No gender difference in initial treatment was found. This study suggests that when designing and analyzing the results from clinical studies of cancer of the larynx, it is important to employ stratification based on gender.
KW - comorbidity
KW - gender
KW - head and neck cancer
KW - prognosis
UR - http://www.scopus.com/inward/record.url?scp=0029006177&partnerID=8YFLogxK
U2 - 10.1177/000348949510400601
DO - 10.1177/000348949510400601
M3 - Article
C2 - 7771712
AN - SCOPUS:0029006177
SN - 0003-4894
VL - 104
SP - 419
EP - 424
JO - Annals of Otology, Rhinology & Laryngology
JF - Annals of Otology, Rhinology & Laryngology
IS - 6
ER -