GDNF released from microspheres enhances nerve regeneration after delayed repair

Matthew D. Wood, Howard Kim, Alex Bilbily, Stephen W.P. Kemp, Christine Lafontaine, Tessa Gordon, Molly S. Shoichet, Gregory H. Borschel

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Introduction: Delays in surgical repair following nerve transection produce progressively inferior motor nerve regeneration. Regeneration can be improved with delivery of exogenous growth factor. We developed a delivery system that could be applied at the nerve repair site to deliver growth factors locally to regenerating nerve. Methods: Poly(lactic-co-glycolic acid) microspheres containing glial-derived neurotrophic factor (GDNF) suspended within fibrin were developed into a delivery system for local application surrounding nerve at a repair site in an experimental rat model. Results: The system containing GDNF remained at the injury site for up to 2 weeks and improved motor nerve regeneration following chronic axotomy and denervation. Conclusions: Based on the positive outcome of the delivery system, we plan to study the delivery system over longer time courses of release and nerve regeneration.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalMuscle and Nerve
Volume46
Issue number1
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

Keywords

  • Chronic axotomy
  • Chronic denervation
  • Common fibular nerve
  • Drug delivery
  • Fibrin
  • Nerve injury

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    Wood, M. D., Kim, H., Bilbily, A., Kemp, S. W. P., Lafontaine, C., Gordon, T., Shoichet, M. S., & Borschel, G. H. (2012). GDNF released from microspheres enhances nerve regeneration after delayed repair. Muscle and Nerve, 46(1), 122-124. https://doi.org/10.1002/mus.23295