Abstract
Introduction: Delays in surgical repair following nerve transection produce progressively inferior motor nerve regeneration. Regeneration can be improved with delivery of exogenous growth factor. We developed a delivery system that could be applied at the nerve repair site to deliver growth factors locally to regenerating nerve. Methods: Poly(lactic-co-glycolic acid) microspheres containing glial-derived neurotrophic factor (GDNF) suspended within fibrin were developed into a delivery system for local application surrounding nerve at a repair site in an experimental rat model. Results: The system containing GDNF remained at the injury site for up to 2 weeks and improved motor nerve regeneration following chronic axotomy and denervation. Conclusions: Based on the positive outcome of the delivery system, we plan to study the delivery system over longer time courses of release and nerve regeneration.
Original language | English |
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Pages (from-to) | 122-124 |
Number of pages | 3 |
Journal | Muscle and Nerve |
Volume | 46 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2012 |
Keywords
- Chronic axotomy
- Chronic denervation
- Common fibular nerve
- Drug delivery
- Fibrin
- Nerve injury