GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

Keyphrases

• Kinase Activation 100%
• Pulmonary Arterial Hypertension 100%
• Pulmonary Vascular Remodeling 100%
• General Control Nonderepressible 2 Kinase 100%
• Endothelin-1 (ET-1) 40%
• Venous Disease 20%
• Hypoxia-induced Pulmonary Hypertension 20%
• Monocrotaline 20%
• EIF2AK4 20%
• RNA-seq Analysis 10%
• Endothelial Cells 10%
• Gain-of-function mutation 10%
• Pulmonary Hypertension 10%
• Downstream Targets 10%
• Kinase Domain 10%
• Therapeutic Strategies 10%
• Kinase Activity 10%
• Hypoxia 10%
• Pulmonary Vascular Resistance 10%
• Kinase Inhibitor 10%
• Idiopathic Pulmonary Arterial Hypertension 10%
• Right Heart Failure 10%
• Recessive mutation 10%
• Pulmonary Microvascular Endothelial Cells (PMVECs) 10%
• HIF-2 10%
• Human Lung Endothelial Cells 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Pulmonary Veno-Occlusive Disease 12%