TY - JOUR
T1 - GATA transcription factors in adrenal development and tumors
AU - Parviainen, Helka
AU - Kiiveri, Sanne
AU - Bielinska, Malgorzata
AU - Rahman, Nafis
AU - Huhtaniemi, Ilpo T.
AU - Wilson, David B.
AU - Heikinheimo, Markku
N1 - Funding Information:
The Finnish Cultural Foundation, the Finnish Foundation for Pediatric Research, and the Sigrid Juselius Foundation financially supported this work.
PY - 2007/2
Y1 - 2007/2
N2 - Of the six GATA transcription factors, GATA-4 and GATA-6 are expressed in the mouse and human adrenal with distinct developmental profiles. GATA-4 is confined to the fetal cortex, i.e. to the less differentiated proliferating cells, while GATA-6 is expressed both in the fetal and adult adrenal. In vitro, GATA-4 regulates inhibin-α and steroidogenic factor-1 implicated in normal adrenal function. GATA-6 probably has roles in the development and differentiation of adrenocortical cells, and in the regulation of steroidogenesis. GATA-4 expression is dramatically upregulated and GATA-6 downregulated in gonadotropin dependent mouse adrenocortical tumors. This is accompanied by the appearance of luteinizing hormone receptor (LHR). In vitro, GATA-4 transactivates LHR promoter, and gonadotropins upregulate GATA-4 levels. Human adrenal tumors occasionally express GATA-4, whereas GATA-6 levels are usually lower than normal.
AB - Of the six GATA transcription factors, GATA-4 and GATA-6 are expressed in the mouse and human adrenal with distinct developmental profiles. GATA-4 is confined to the fetal cortex, i.e. to the less differentiated proliferating cells, while GATA-6 is expressed both in the fetal and adult adrenal. In vitro, GATA-4 regulates inhibin-α and steroidogenic factor-1 implicated in normal adrenal function. GATA-6 probably has roles in the development and differentiation of adrenocortical cells, and in the regulation of steroidogenesis. GATA-4 expression is dramatically upregulated and GATA-6 downregulated in gonadotropin dependent mouse adrenocortical tumors. This is accompanied by the appearance of luteinizing hormone receptor (LHR). In vitro, GATA-4 transactivates LHR promoter, and gonadotropins upregulate GATA-4 levels. Human adrenal tumors occasionally express GATA-4, whereas GATA-6 levels are usually lower than normal.
KW - Gonadectomy
KW - Inhibin
KW - Luteinizing hormone
KW - Metaplasia
KW - Steroidogenesis
UR - http://www.scopus.com/inward/record.url?scp=33847049383&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2006.12.033
DO - 10.1016/j.mce.2006.12.033
M3 - Review article
C2 - 17207921
AN - SCOPUS:33847049383
SN - 0303-7207
VL - 265-266
SP - 17
EP - 22
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - SUPPL.
ER -