TY - JOUR
T1 - GATA factors in endocrine neoplasia
AU - Pihlajoki, Marjut
AU - Färkkilä, Anniina
AU - Soini, Tea
AU - Heikinheimo, Markku
AU - Wilson, David B.
N1 - Funding Information:
We apologize to investigators whose work was not directly cited due to space limitations. We thank Leila Unkila-Kallio and Jorma Toppari for a critical reading of the manuscript. We thank Ilkka Ketola and Sanne Kiiveri for providing photomicrographs, Matti Kiupel for providing ferret tumor specimens, and Rebecca Cochran for technical support. Grant support: NIH ( DK075618 ), AHA ( 13GRNT16850031 ), DOD grant PC141008 , the Sigrid Jusélius Foundation , and the Academy of Finland .
Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2016/2/5
Y1 - 2016/2/5
N2 - GATA transcription factors are structurally-related zinc finger proteins that recognize the consensus DNA sequence WGATAA (the GATA motif), an essential cis-acting element in the promoters and enhancers of many genes. These transcription factors regulate cell fate specification and differentiation in a wide array of tissues. As demonstrated by genetic analyses of mice and humans, GATA factors play pivotal roles in the development, homeostasis, and function of several endocrine organs including the adrenal cortex, ovary, pancreas, parathyroid, pituitary, and testis. Additionally, GATA factors have been shown to be mutated, overexpressed, or underexpressed in a variety of endocrine tumors (. e.g., adrenocortical neoplasms, parathyroid tumors, pituitary adenomas, and sex cord stromal tumors). Emerging evidence suggests that GATA factors play a direct role in the initiation, proliferation, or propagation of certain endocrine tumors via modulation of key developmental signaling pathways implicated in oncogenesis, such as the WNT/β-catenin and TGFβ pathways. Altered expression or function of GATA factors can also affect the metabolism, ploidy, and invasiveness of tumor cells. This article provides an overview of the role of GATA factors in endocrine neoplasms. Relevant animal models are highlighted.
AB - GATA transcription factors are structurally-related zinc finger proteins that recognize the consensus DNA sequence WGATAA (the GATA motif), an essential cis-acting element in the promoters and enhancers of many genes. These transcription factors regulate cell fate specification and differentiation in a wide array of tissues. As demonstrated by genetic analyses of mice and humans, GATA factors play pivotal roles in the development, homeostasis, and function of several endocrine organs including the adrenal cortex, ovary, pancreas, parathyroid, pituitary, and testis. Additionally, GATA factors have been shown to be mutated, overexpressed, or underexpressed in a variety of endocrine tumors (. e.g., adrenocortical neoplasms, parathyroid tumors, pituitary adenomas, and sex cord stromal tumors). Emerging evidence suggests that GATA factors play a direct role in the initiation, proliferation, or propagation of certain endocrine tumors via modulation of key developmental signaling pathways implicated in oncogenesis, such as the WNT/β-catenin and TGFβ pathways. Altered expression or function of GATA factors can also affect the metabolism, ploidy, and invasiveness of tumor cells. This article provides an overview of the role of GATA factors in endocrine neoplasms. Relevant animal models are highlighted.
KW - Adrenocortical tumor
KW - Granulosa cell tumor
KW - Parathyroid tumor
KW - Pituitary adenoma
KW - Sertoli-Leydig cell tumor
UR - http://www.scopus.com/inward/record.url?scp=84953635159&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2015.05.027
DO - 10.1016/j.mce.2015.05.027
M3 - Review article
C2 - 26027919
AN - SCOPUS:84953635159
SN - 0303-7207
VL - 421
SP - 2
EP - 17
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
ER -