TY - JOUR
T1 - Gastrulation in zebrafish - all just about adhesion?
AU - Solnica-Krezel, Lilianna
N1 - Funding Information:
I would like to thank Josh Gamse, Jason Jessen, Alex Schier and members of my laboratory for instructive comments on the manuscript. I apologize to all colleagues that, owing to space limitations, not all relevant primary studies could be cited. Work on gastrulation in my laboratory has been supported by grants from National Institutes of Health, GM55101 and GM77770.
PY - 2006/8
Y1 - 2006/8
N2 - During vertebrate gastrulation, the evolutionarily conserved morphogenetic movements of epiboly, internalization, convergence and extension cooperate to generate germ layers and to sculpt the body plan. In zebrafish, these movements are driven by a variety of cell behaviors, including slow and fast directed migration, radial and mediolateral intercalation, and cell shape changes. Whereas some signaling pathways are required for a subset of these behaviors, other molecules, such as E-cadherin or Gα12 and Gα13 proteins, appear to have a widespread role in different gastrulation cell behaviors.
AB - During vertebrate gastrulation, the evolutionarily conserved morphogenetic movements of epiboly, internalization, convergence and extension cooperate to generate germ layers and to sculpt the body plan. In zebrafish, these movements are driven by a variety of cell behaviors, including slow and fast directed migration, radial and mediolateral intercalation, and cell shape changes. Whereas some signaling pathways are required for a subset of these behaviors, other molecules, such as E-cadherin or Gα12 and Gα13 proteins, appear to have a widespread role in different gastrulation cell behaviors.
UR - http://www.scopus.com/inward/record.url?scp=33745611527&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2006.06.009
DO - 10.1016/j.gde.2006.06.009
M3 - Review article
C2 - 16797963
AN - SCOPUS:33745611527
SN - 0959-437X
VL - 16
SP - 433
EP - 441
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 4
ER -