Gastric plexiform schwannoma in association with neurofibromatosis type 2

Satoru Kudose, Michael Kyriakos, Michael Magdi Awad

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Plexiform schwannoma (PS) is an uncommon variant of schwannoma characterized by a multinodular (plexiform) growth pattern. It comprises up to 5 % of all schwannomas. The association between PS and neurofibromatosis type 1 or type 2 (NF1/NF2) is only rarely reported. Most cases of PS occur in the skin and subcutaneous soft tissue, with only a few reports of digestive tract involvement. We describe an 18-year-old male with NF2 who had bilateral vestibular schwannomas and multiple cutaneous PSs, and a 3-year history of abdominal pain. The patient ultimately underwent a distal gastrectomy for a partially obstructing submucosal antral mass, associated with an overlying ulcer. Histopathologic examination showed the mass to be a PS. The patient is alive and well, without symptoms, 12 months postoperatively. A review of the English language medical literature yielded only ten examples of PS arising in the digestive tract. Our patient is the first to be reported to have a gastric PS, and only the second patient to be reported with a digestive tract PS to have NF2, and the only patient reported to have both digestive tract and cutaneous PSs. Despite its rare occurrence with NF2, the finding of PS at any site should stimulate an examination for other manifestations of this disorder. Clinical Trial Registration: None.

Original languageEnglish
Pages (from-to)352-357
Number of pages6
JournalClinical Journal of Gastroenterology
Volume9
Issue number6
DOIs
StatePublished - Dec 1 2016

Keywords

  • Plexiform schwannoma
  • Stomach

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