GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide

the GARFIELD-AF Investigators; Sylvia Haas; John A. Camm; Darius Harald; Jan Steffel; Saverio Virdone; Karen Pieper; Marianne Brodmann; Sebastian Schellong; Frank Misselwitz; Gloria Kayani; Ajay K. Kakkar; Ajay K. Kakkar; Jean Pierre Bassand; A. John Camm; David A. Fitzmaurice; Keith A.A. Fox; Bernard J. Gersh; Samuel Z. Goldhaber; Shinya Goto; Sylvia Haas; Werner Hacke; Lorenzo G. Mantovani; Frank Misselwitz; Karen S. Pieper; Alexander G.G. Turpie; Martin van Eickels; Freek W.A. Verheugt; Keith A.A.Fox Bernard J. Gersh; Hector Lucas Luciardi Harry Gibbs; Marianne Brodmann; Frank Cools; Antonio Carlos Pereira Barretto; Stuart J. Connolly; John Eikelboom; Ramon Corbalan; Zhi Cheng Jing; Petr Jansky; Jørn Dalsgaard Nielsen; Hany Ragy; Pekka Raatikainen; Jean Yves Le Heuzey; Harald Darius; Matyas Keltai; Jitendra Pal Singh Sawhney; Giancarlo Agnelli; Giuseppe Ambrosio; Yukihiro Koretsune; Carlos Jerjes Sánchez Díaz; Hugo Ten Cate; Dan Atar; Janina Stepinska; Elizaveta Panchenko; Toon Wei Lim; Barry Jacobson; Seil Oh; Xavier Viñolas; Marten Rosenqvist; Jan Steffel; Pantep Angchaisuksiri; Ali Oto; Alex Parkhomenko; Wael Al Mahmeed; David Fitzmaurice; Samuel Z. Goldhaber; Dayi Hu Kangning Chen; Yusheng Zhao; Huaiqin Zhang; Jiyan Chen; Shiping Cao; Daowen Wang; Yuejin Yang; Weihua Li; Hui Li; Yuehui Yin; Guizhou Tao; Ping Yang; Yingmin Chen; Shenghu He; Yong Wang; Guosheng Fu; Xin Li; Tongguo Wu; Xiaoshu Cheng; Xiaowei Yan; Ruiping Zhao; Moshui Chen; Longgen Xiong; Ping Chen; Yang Jiao; Ying Guo; Li Xue; Zhiming Yang; Praveen Jadhavm Raghava Sarma; Govind Kulkarni; Prakash Chandwani; Rasesh Atulbhai Pothiwala; Mohanan Padinhare Purayil; Kamaldeep Chawla; Veerappa Annasaheb Kothiwale; Bagirath Raghuraman; Vinod Madan Vijan; Jitendra Sawhney; Ganapathi Bantwal; Aziz Khan; Ramdhan Meena; Manojkumar Chopada; Sunitha Abraham; Vikas Bisne; Govindan Vijayaraghavan; Debabrata Roy; Rajashekhar Durgaprasad; A. G.Ravi Shankar; Sunil Kumar; Dinesh Jain; Kartikeya Bhargava; Vinay Kumar; Udigala Madappa Nagamalesh; Rajeeve Kumar Rajput; Yukihiro Koretsune Seishu Kanamori; Kenichi Yamamoto; Koichiro Kumagai; Yosuke Katsuda; Keiki Yoshida; Fumitoshi Toyota; Yuji Mizuno; Ikuo Misumi; Hiroo Noguchi; Shinichi Ando; Tetsuro Suetsugu; Masahiro Minamoto; Hiroyuki Oda; Susumu Adachi; Kei Chiba; Hiroaki Norita; Makoto Tsuruta; Takeshi Koyanagi; Kunihiko Yamamoto; Hiroshi Ando; Takayuki Higashi; Megumi Okada; Shiro Azakami; Shinichiro Komaki; Kenshi Kumeda; Takashi Murayama; Jun Matsumura; Yurika Oba; Ryuji Sonoda; Kazuo Goto; Kotaro Minoda; Yoshikuni Haraguchi; Hisakazu Suefuji; Hiroo Miyagi; Hitoshi Kato; Tsugihiro Nakamura; Tadashi Nakamura; Hidekazu Nandate; Ryuji Zaitsu; Yoshihisa Fujiura; Akira Yoshimura; Hiroyuki Numata; Jun Ogawa; Yasuyuki Kamogawa; Kinshiro Murakami; Yutaka Wakasa; Masanori Yamasawa; Hiromitsu Maekawa; Sumihisa Abe; Hajime Kihara; Satoru Tsunoda; Katsumi Saito; Hiroki Tachibana; Ichiro Oba; Takashi Kuwahata; Satoshi Higa; Masamichi Gushiken; Takuma Eto; Hidetoshi Chibana; Kazuaki Fujisawa; Yuhei Shiga; Hirokuni Sumi; Toshihisa Nagatomo; Yoshihiko Atsuchi; Toshiro Nagoshi; Kazuhisa Sanno; Fumihiro Hoshino; Naoto Yokota; Masahiro Kameko; Toshifumi Tabuchi; Munesumi Ishizawa; Yoshitake Fujiura; Daisuke Ikeda; Taku Seto; Tetsu Iwao; Norio Ishioka; Koichi Oshiro; Keizo Tsuchida; Yutaka Hatori; Motoshi Takeuchi; Hiroto Takezawa; Daniel Theodoro

doi:10.1007/s00392-022-02079-y

GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide

the GARFIELD-AF Investigators, Sylvia Haas, John A. Camm, Darius Harald, Jan Steffel, Saverio Virdone, Karen Pieper, Marianne Brodmann, Sebastian Schellong, Frank Misselwitz, Gloria Kayani, Ajay K. Kakkar, Ajay K. Kakkar, Jean Pierre Bassand, A. John Camm, David A. Fitzmaurice, Keith A.A. Fox, Bernard J. Gersh, Samuel Z. Goldhaber, Shinya GotoSylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Karen S. Pieper, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Keith A.A.Fox Bernard J. Gersh, Hector Lucas Luciardi Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, John Eikelboom, Ramon Corbalan, Zhi Cheng Jing, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean Yves Le Heuzey, Harald Darius, Matyas Keltai, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, Samuel Z. Goldhaber, Dayi Hu Kangning Chen, Yusheng Zhao, Huaiqin Zhang, Jiyan Chen, Shiping Cao, Daowen Wang, Yuejin Yang, Weihua Li, Hui Li, Yuehui Yin, Guizhou Tao, Ping Yang, Yingmin Chen, Shenghu He, Yong Wang, Guosheng Fu, Xin Li, Tongguo Wu, Xiaoshu Cheng, Xiaowei Yan, Ruiping Zhao, Moshui Chen, Longgen Xiong, Ping Chen, Yang Jiao, Ying Guo, Li Xue, Zhiming Yang, Praveen Jadhavm Raghava Sarma, Govind Kulkarni, Prakash Chandwani, Rasesh Atulbhai Pothiwala, Mohanan Padinhare Purayil, Kamaldeep Chawla, Veerappa Annasaheb Kothiwale, Bagirath Raghuraman, Vinod Madan Vijan, Jitendra Sawhney, Ganapathi Bantwal, Aziz Khan, Ramdhan Meena, Manojkumar Chopada, Sunitha Abraham, Vikas Bisne, Govindan Vijayaraghavan, Debabrata Roy, Rajashekhar Durgaprasad, A. G.Ravi Shankar, Sunil Kumar, Dinesh Jain, Kartikeya Bhargava, Vinay Kumar, Udigala Madappa Nagamalesh, Rajeeve Kumar Rajput, Yukihiro Koretsune Seishu Kanamori, Kenichi Yamamoto, Koichiro Kumagai, Yosuke Katsuda, Keiki Yoshida, Fumitoshi Toyota, Yuji Mizuno, Ikuo Misumi, Hiroo Noguchi, Shinichi Ando, Tetsuro Suetsugu, Masahiro Minamoto, Hiroyuki Oda, Susumu Adachi, Kei Chiba, Hiroaki Norita, Makoto Tsuruta, Takeshi Koyanagi, Kunihiko Yamamoto, Hiroshi Ando, Takayuki Higashi, Megumi Okada, Shiro Azakami, Shinichiro Komaki, Kenshi Kumeda, Takashi Murayama, Jun Matsumura, Yurika Oba, Ryuji Sonoda, Kazuo Goto, Kotaro Minoda, Yoshikuni Haraguchi, Hisakazu Suefuji, Hiroo Miyagi, Hitoshi Kato, Tsugihiro Nakamura, Tadashi Nakamura, Hidekazu Nandate, Ryuji Zaitsu, Yoshihisa Fujiura, Akira Yoshimura, Hiroyuki Numata, Jun Ogawa, Yasuyuki Kamogawa, Kinshiro Murakami, Yutaka Wakasa, Masanori Yamasawa, Hiromitsu Maekawa, Sumihisa Abe, Hajime Kihara, Satoru Tsunoda, Katsumi Saito, Hiroki Tachibana, Ichiro Oba, Takashi Kuwahata, Satoshi Higa, Masamichi Gushiken, Takuma Eto, Hidetoshi Chibana, Kazuaki Fujisawa, Yuhei Shiga, Hirokuni Sumi, Toshihisa Nagatomo, Yoshihiko Atsuchi, Toshiro Nagoshi, Kazuhisa Sanno, Fumihiro Hoshino, Naoto Yokota, Masahiro Kameko, Toshifumi Tabuchi, Munesumi Ishizawa, Yoshitake Fujiura, Daisuke Ikeda, Taku Seto, Tetsu Iwao, Norio Ishioka, Koichi Oshiro, Keizo Tsuchida, Yutaka Hatori, Motoshi Takeuchi, Hiroto Takezawa, Daniel Theodoro

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is a worldwide non-interventional study of stroke prevention in patients with non-valvular AF. Methods and results: 52,080 patients with newly diagnosed AF were prospectively enrolled from 2010 to 2016. 4121 (7.9%) of these patients were recruited in DACH [Germany (n = 3567), Austria (n = 465) and Switzerland (n = 89) combined], and 47,959 patients were from 32 countries in other regions worldwide (ORW). Hypertension was most prevalent in DACH and ORW (85.3% and 75.6%, respectively). Diabetes, hypercholesterolaemia, carotid occlusive disease and vascular disease were more prevalent in DACH patients vs ORW (27.6%, 49.4%, 5.8% and 29.0% vs 21.7%, 40.9%, 2.8% and 24.5%). The use of non-vitamin K antagonist oral anticoagulants (NOACs) increased more in DACH over time. Management of vitamin K antagonists was suboptimal in DACH and ORW (time in therapeutic range of INR ≥ 65% in 44.6% and 44.4% of patients or ≥ 70% in 36.9% and 36.0% of patients, respectively). Adjusted rates of cardiovascular mortality and MI/ACS were higher in DACH while non-haemorrhagic stroke/systemic embolism was lower after 2-year follow-up. Conclusions: Similarities and dissimilarities in AF management and clinical outcomes are seen in DACH and ORW. The increased use of NOAC was associated with a mismatch of risk-adapted anticoagulation (over-and-undertreatment) in DACH. Suboptimal control of INR requires educational activities in both regional groups. Higher rates of cardiovascular death in DACH may reflect the higher risk profile of these patients and lower rates of non-haemorrhagic stroke could be associated with increased NOAC use. Graphical abstract: [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	759-771
Number of pages	13
Journal	Clinical Research in Cardiology
Volume	112
Issue number	6
DOIs	https://doi.org/10.1007/s00392-022-02079-y
State	Published - Jun 2023

Keywords

Atrial fibrillation
GARFIELD-AF
Non-vitamin K antagonist oral anticoagulants
Oral anticoagulation
Phenprocoumon
Vitamin K antagonists

Access to Document

10.1007/s00392-022-02079-y

Cite this

the GARFIELD-AF Investigators, Haas, S., Camm, J. A., Harald, D., Steffel, J., Virdone, S., Pieper, K., Brodmann, M., Schellong, S., Misselwitz, F., Kayani, G., Kakkar, A. K., Kakkar, A. K., Bassand, J. P., Camm, A. J., Fitzmaurice, D. A., Fox, K. A. A., Gersh, B. J., Goldhaber, S. Z., ... Theodoro, D. (2023). GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide. Clinical Research in Cardiology, 112(6), 759-771. https://doi.org/10.1007/s00392-022-02079-y

@article{df9242dd7d1644419ad70b904e959fb1,

title = "GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide",

abstract = "Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is a worldwide non-interventional study of stroke prevention in patients with non-valvular AF. Methods and results: 52,080 patients with newly diagnosed AF were prospectively enrolled from 2010 to 2016. 4121 (7.9%) of these patients were recruited in DACH [Germany (n = 3567), Austria (n = 465) and Switzerland (n = 89) combined], and 47,959 patients were from 32 countries in other regions worldwide (ORW). Hypertension was most prevalent in DACH and ORW (85.3% and 75.6%, respectively). Diabetes, hypercholesterolaemia, carotid occlusive disease and vascular disease were more prevalent in DACH patients vs ORW (27.6%, 49.4%, 5.8% and 29.0% vs 21.7%, 40.9%, 2.8% and 24.5%). The use of non-vitamin K antagonist oral anticoagulants (NOACs) increased more in DACH over time. Management of vitamin K antagonists was suboptimal in DACH and ORW (time in therapeutic range of INR ≥ 65% in 44.6% and 44.4% of patients or ≥ 70% in 36.9% and 36.0% of patients, respectively). Adjusted rates of cardiovascular mortality and MI/ACS were higher in DACH while non-haemorrhagic stroke/systemic embolism was lower after 2-year follow-up. Conclusions: Similarities and dissimilarities in AF management and clinical outcomes are seen in DACH and ORW. The increased use of NOAC was associated with a mismatch of risk-adapted anticoagulation (over-and-undertreatment) in DACH. Suboptimal control of INR requires educational activities in both regional groups. Higher rates of cardiovascular death in DACH may reflect the higher risk profile of these patients and lower rates of non-haemorrhagic stroke could be associated with increased NOAC use. Graphical abstract: [Figure not available: see fulltext.].",

keywords = "Atrial fibrillation, GARFIELD-AF, Non-vitamin K antagonist oral anticoagulants, Oral anticoagulation, Phenprocoumon, Vitamin K antagonists",

author = "{the GARFIELD-AF Investigators} and Sylvia Haas and Camm, {John A.} and Darius Harald and Jan Steffel and Saverio Virdone and Karen Pieper and Marianne Brodmann and Sebastian Schellong and Frank Misselwitz and Gloria Kayani and Kakkar, {Ajay K.} and Kakkar, {Ajay K.} and Bassand, {Jean Pierre} and Camm, {A. John} and Fitzmaurice, {David A.} and Fox, {Keith A.A.} and Gersh, {Bernard J.} and Goldhaber, {Samuel Z.} and Shinya Goto and Sylvia Haas and Werner Hacke and Mantovani, {Lorenzo G.} and Frank Misselwitz and Pieper, {Karen S.} and Turpie, {Alexander G.G.} and {van Eickels}, Martin and Verheugt, {Freek W.A.} and Gersh, {Keith A.A.Fox Bernard J.} and Gibbs, {Hector Lucas Luciardi Harry} and Marianne Brodmann and Frank Cools and Barretto, {Antonio Carlos Pereira} and Connolly, {Stuart J.} and John Eikelboom and Ramon Corbalan and Jing, {Zhi Cheng} and Petr Jansky and Nielsen, {J{\o}rn Dalsgaard} and Hany Ragy and Pekka Raatikainen and {Le Heuzey}, {Jean Yves} and Harald Darius and Matyas Keltai and Sawhney, {Jitendra Pal Singh} and Giancarlo Agnelli and Giuseppe Ambrosio and Yukihiro Koretsune and D{\'i}az, {Carlos Jerjes S{\'a}nchez} and Cate, {Hugo Ten} and Dan Atar and Janina Stepinska and Elizaveta Panchenko and Lim, {Toon Wei} and Barry Jacobson and Seil Oh and Xavier Vi{\~n}olas and Marten Rosenqvist and Jan Steffel and Pantep Angchaisuksiri and Ali Oto and Alex Parkhomenko and {Al Mahmeed}, Wael and David Fitzmaurice and Goldhaber, {Samuel Z.} and Chen, {Dayi Hu Kangning} and Yusheng Zhao and Huaiqin Zhang and Jiyan Chen and Shiping Cao and Daowen Wang and Yuejin Yang and Weihua Li and Hui Li and Yuehui Yin and Guizhou Tao and Ping Yang and Yingmin Chen and Shenghu He and Yong Wang and Guosheng Fu and Xin Li and Tongguo Wu and Xiaoshu Cheng and Xiaowei Yan and Ruiping Zhao and Moshui Chen and Longgen Xiong and Ping Chen and Yang Jiao and Ying Guo and Li Xue and Zhiming Yang and Sarma, {Praveen Jadhavm Raghava} and Govind Kulkarni and Prakash Chandwani and Pothiwala, {Rasesh Atulbhai} and Purayil, {Mohanan Padinhare} and Kamaldeep Chawla and Kothiwale, {Veerappa Annasaheb} and Bagirath Raghuraman and Vijan, {Vinod Madan} and Jitendra Sawhney and Ganapathi Bantwal and Aziz Khan and Ramdhan Meena and Manojkumar Chopada and Sunitha Abraham and Vikas Bisne and Govindan Vijayaraghavan and Debabrata Roy and Rajashekhar Durgaprasad and Shankar, {A. G.Ravi} and Sunil Kumar and Dinesh Jain and Kartikeya Bhargava and Vinay Kumar and Nagamalesh, {Udigala Madappa} and Rajput, {Rajeeve Kumar} and Kanamori, {Yukihiro Koretsune Seishu} and Kenichi Yamamoto and Koichiro Kumagai and Yosuke Katsuda and Keiki Yoshida and Fumitoshi Toyota and Yuji Mizuno and Ikuo Misumi and Hiroo Noguchi and Shinichi Ando and Tetsuro Suetsugu and Masahiro Minamoto and Hiroyuki Oda and Susumu Adachi and Kei Chiba and Hiroaki Norita and Makoto Tsuruta and Takeshi Koyanagi and Kunihiko Yamamoto and Hiroshi Ando and Takayuki Higashi and Megumi Okada and Shiro Azakami and Shinichiro Komaki and Kenshi Kumeda and Takashi Murayama and Jun Matsumura and Yurika Oba and Ryuji Sonoda and Kazuo Goto and Kotaro Minoda and Yoshikuni Haraguchi and Hisakazu Suefuji and Hiroo Miyagi and Hitoshi Kato and Tsugihiro Nakamura and Tadashi Nakamura and Hidekazu Nandate and Ryuji Zaitsu and Yoshihisa Fujiura and Akira Yoshimura and Hiroyuki Numata and Jun Ogawa and Yasuyuki Kamogawa and Kinshiro Murakami and Yutaka Wakasa and Masanori Yamasawa and Hiromitsu Maekawa and Sumihisa Abe and Hajime Kihara and Satoru Tsunoda and Katsumi Saito and Hiroki Tachibana and Ichiro Oba and Takashi Kuwahata and Satoshi Higa and Masamichi Gushiken and Takuma Eto and Hidetoshi Chibana and Kazuaki Fujisawa and Yuhei Shiga and Hirokuni Sumi and Toshihisa Nagatomo and Yoshihiko Atsuchi and Toshiro Nagoshi and Kazuhisa Sanno and Fumihiro Hoshino and Naoto Yokota and Masahiro Kameko and Toshifumi Tabuchi and Munesumi Ishizawa and Yoshitake Fujiura and Daisuke Ikeda and Taku Seto and Tetsu Iwao and Norio Ishioka and Koichi Oshiro and Keizo Tsuchida and Yutaka Hatori and Motoshi Takeuchi and Hiroto Takezawa and Daniel Theodoro",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.",

year = "2023",

month = jun,

doi = "10.1007/s00392-022-02079-y",

language = "English",

volume = "112",

pages = "759--771",

journal = "Clinical Research in Cardiology",

issn = "1861-0684",

number = "6",

}

the GARFIELD-AF Investigators, Haas, S, Camm, JA, Harald, D, Steffel, J, Virdone, S, Pieper, K, Brodmann, M, Schellong, S, Misselwitz, F, Kayani, G, Kakkar, AK, Kakkar, AK, Bassand, JP, Camm, AJ, Fitzmaurice, DA, Fox, KAA, Gersh, BJ, Goldhaber, SZ, Goto, S, Haas, S, Hacke, W, Mantovani, LG, Misselwitz, F, Pieper, KS, Turpie, AGG, van Eickels, M, Verheugt, FWA, Gersh, KAAFBJ, Gibbs, HLLH, Brodmann, M, Cools, F, Barretto, ACP, Connolly, SJ, Eikelboom, J, Corbalan, R, Jing, ZC, Jansky, P, Nielsen, JD, Ragy, H, Raatikainen, P, Le Heuzey, JY, Darius, H, Keltai, M, Sawhney, JPS, Agnelli, G, Ambrosio, G, Koretsune, Y, Díaz, CJS, Cate, HT, Atar, D, Stepinska, J, Panchenko, E, Lim, TW, Jacobson, B, Oh, S, Viñolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Oto, A, Parkhomenko, A, Al Mahmeed, W, Fitzmaurice, D, Goldhaber, SZ, Chen, DHK, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Li, H, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Yang, Z, Sarma, PJR, Kulkarni, G, Chandwani, P, Pothiwala, RA, Purayil, MP, Chawla, K, Kothiwale, VA, Raghuraman, B, Vijan, VM, Sawhney, J, Bantwal, G, Khan, A, Meena, R, Chopada, M, Abraham, S, Bisne, V, Vijayaraghavan, G, Roy, D, Durgaprasad, R, Shankar, AGR, Kumar, S, Jain, D, Bhargava, K, Kumar, V, Nagamalesh, UM, Rajput, RK, Kanamori, YKS, Yamamoto, K, Kumagai, K, Katsuda, Y, Yoshida, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Yamamoto, K, Ando, H, Higashi, T, Okada, M, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Chibana, H, Fujisawa, K, Shiga, Y, Sumi, H, Nagatomo, T, Atsuchi, Y, Nagoshi, T, Sanno, K, Hoshino, F, Yokota, N, Kameko, M, Tabuchi, T, Ishizawa, M, Fujiura, Y, Ikeda, D, Seto, T, Iwao, T, Ishioka, N, Oshiro, K, Tsuchida, K, Hatori, Y, Takeuchi, M, Takezawa, H & Theodoro, D 2023, 'GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide', Clinical Research in Cardiology, vol. 112, no. 6, pp. 759-771. https://doi.org/10.1007/s00392-022-02079-y

GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide. / the GARFIELD-AF Investigators; Haas, Sylvia; Camm, John A. et al.
In: Clinical Research in Cardiology, Vol. 112, No. 6, 06.2023, p. 759-771.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - GARFIELD-AF

T2 - risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide

AU - the GARFIELD-AF Investigators

AU - Haas, Sylvia

AU - Camm, John A.

AU - Harald, Darius

AU - Steffel, Jan

AU - Virdone, Saverio

AU - Pieper, Karen

AU - Brodmann, Marianne

AU - Schellong, Sebastian

AU - Misselwitz, Frank

AU - Kayani, Gloria

AU - Kakkar, Ajay K.

AU - Bassand, Jean Pierre

AU - Camm, A. John

AU - Fitzmaurice, David A.

AU - Fox, Keith A.A.

AU - Gersh, Bernard J.

AU - Goldhaber, Samuel Z.

AU - Goto, Shinya

AU - Haas, Sylvia

AU - Hacke, Werner

AU - Mantovani, Lorenzo G.

AU - Misselwitz, Frank

AU - Pieper, Karen S.

AU - Turpie, Alexander G.G.

AU - van Eickels, Martin

AU - Verheugt, Freek W.A.

AU - Gersh, Keith A.A.Fox Bernard J.

AU - Gibbs, Hector Lucas Luciardi Harry

AU - Brodmann, Marianne

AU - Cools, Frank

AU - Barretto, Antonio Carlos Pereira

AU - Connolly, Stuart J.

AU - Eikelboom, John

AU - Corbalan, Ramon

AU - Jing, Zhi Cheng

AU - Jansky, Petr

AU - Nielsen, Jørn Dalsgaard

AU - Ragy, Hany

AU - Raatikainen, Pekka

AU - Le Heuzey, Jean Yves

AU - Darius, Harald

AU - Keltai, Matyas

AU - Sawhney, Jitendra Pal Singh

AU - Agnelli, Giancarlo

AU - Ambrosio, Giuseppe

AU - Koretsune, Yukihiro

AU - Díaz, Carlos Jerjes Sánchez

AU - Cate, Hugo Ten

AU - Atar, Dan

AU - Stepinska, Janina

AU - Panchenko, Elizaveta

AU - Lim, Toon Wei

AU - Jacobson, Barry

AU - Oh, Seil

AU - Viñolas, Xavier

AU - Rosenqvist, Marten

AU - Steffel, Jan

AU - Angchaisuksiri, Pantep

AU - Oto, Ali

AU - Parkhomenko, Alex

AU - Al Mahmeed, Wael

AU - Fitzmaurice, David

AU - Goldhaber, Samuel Z.

AU - Chen, Dayi Hu Kangning

AU - Zhao, Yusheng

AU - Zhang, Huaiqin

AU - Chen, Jiyan

AU - Cao, Shiping

AU - Wang, Daowen

AU - Yang, Yuejin

AU - Li, Weihua

AU - Li, Hui

AU - Yin, Yuehui

AU - Tao, Guizhou

AU - Yang, Ping

AU - Chen, Yingmin

AU - He, Shenghu

AU - Wang, Yong

AU - Fu, Guosheng

AU - Li, Xin

AU - Wu, Tongguo

AU - Cheng, Xiaoshu

AU - Yan, Xiaowei

AU - Zhao, Ruiping

AU - Chen, Moshui

AU - Xiong, Longgen

AU - Chen, Ping

AU - Jiao, Yang

AU - Guo, Ying

AU - Xue, Li

AU - Yang, Zhiming

AU - Sarma, Praveen Jadhavm Raghava

AU - Kulkarni, Govind

AU - Chandwani, Prakash

AU - Pothiwala, Rasesh Atulbhai

AU - Purayil, Mohanan Padinhare

AU - Chawla, Kamaldeep

AU - Kothiwale, Veerappa Annasaheb

AU - Raghuraman, Bagirath

AU - Vijan, Vinod Madan

AU - Sawhney, Jitendra

AU - Bantwal, Ganapathi

AU - Khan, Aziz

AU - Meena, Ramdhan

AU - Chopada, Manojkumar

AU - Abraham, Sunitha

AU - Bisne, Vikas

AU - Vijayaraghavan, Govindan

AU - Roy, Debabrata

AU - Durgaprasad, Rajashekhar

AU - Shankar, A. G.Ravi

AU - Kumar, Sunil

AU - Jain, Dinesh

AU - Bhargava, Kartikeya

AU - Kumar, Vinay

AU - Nagamalesh, Udigala Madappa

AU - Rajput, Rajeeve Kumar

AU - Kanamori, Yukihiro Koretsune Seishu

AU - Yamamoto, Kenichi

AU - Kumagai, Koichiro

AU - Katsuda, Yosuke

AU - Yoshida, Keiki

AU - Toyota, Fumitoshi

AU - Mizuno, Yuji

AU - Misumi, Ikuo

AU - Noguchi, Hiroo

AU - Ando, Shinichi

AU - Suetsugu, Tetsuro

AU - Minamoto, Masahiro

AU - Oda, Hiroyuki

AU - Adachi, Susumu

AU - Chiba, Kei

AU - Norita, Hiroaki

AU - Tsuruta, Makoto

AU - Koyanagi, Takeshi

AU - Yamamoto, Kunihiko

AU - Ando, Hiroshi

AU - Higashi, Takayuki

AU - Okada, Megumi

AU - Azakami, Shiro

AU - Komaki, Shinichiro

AU - Kumeda, Kenshi

AU - Murayama, Takashi

AU - Matsumura, Jun

AU - Oba, Yurika

AU - Sonoda, Ryuji

AU - Goto, Kazuo

AU - Minoda, Kotaro

AU - Haraguchi, Yoshikuni

AU - Suefuji, Hisakazu

AU - Miyagi, Hiroo

AU - Kato, Hitoshi

AU - Nakamura, Tsugihiro

AU - Nakamura, Tadashi

AU - Nandate, Hidekazu

AU - Zaitsu, Ryuji

AU - Fujiura, Yoshihisa

AU - Yoshimura, Akira

AU - Numata, Hiroyuki

AU - Ogawa, Jun

AU - Kamogawa, Yasuyuki

AU - Murakami, Kinshiro

AU - Wakasa, Yutaka

AU - Yamasawa, Masanori

AU - Maekawa, Hiromitsu

AU - Abe, Sumihisa

AU - Kihara, Hajime

AU - Tsunoda, Satoru

AU - Saito, Katsumi

AU - Tachibana, Hiroki

AU - Oba, Ichiro

AU - Kuwahata, Takashi

AU - Higa, Satoshi

AU - Gushiken, Masamichi

AU - Eto, Takuma

AU - Chibana, Hidetoshi

AU - Fujisawa, Kazuaki

AU - Shiga, Yuhei

AU - Sumi, Hirokuni

AU - Nagatomo, Toshihisa

AU - Atsuchi, Yoshihiko

AU - Nagoshi, Toshiro

AU - Sanno, Kazuhisa

AU - Hoshino, Fumihiro

AU - Yokota, Naoto

AU - Kameko, Masahiro

AU - Tabuchi, Toshifumi

AU - Ishizawa, Munesumi

AU - Fujiura, Yoshitake

AU - Ikeda, Daisuke

AU - Seto, Taku

AU - Iwao, Tetsu

AU - Ishioka, Norio

AU - Oshiro, Koichi

AU - Tsuchida, Keizo

AU - Hatori, Yutaka

AU - Takeuchi, Motoshi

AU - Takezawa, Hiroto

AU - Theodoro, Daniel

PY - 2023/6

Y1 - 2023/6

N2 - Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is a worldwide non-interventional study of stroke prevention in patients with non-valvular AF. Methods and results: 52,080 patients with newly diagnosed AF were prospectively enrolled from 2010 to 2016. 4121 (7.9%) of these patients were recruited in DACH [Germany (n = 3567), Austria (n = 465) and Switzerland (n = 89) combined], and 47,959 patients were from 32 countries in other regions worldwide (ORW). Hypertension was most prevalent in DACH and ORW (85.3% and 75.6%, respectively). Diabetes, hypercholesterolaemia, carotid occlusive disease and vascular disease were more prevalent in DACH patients vs ORW (27.6%, 49.4%, 5.8% and 29.0% vs 21.7%, 40.9%, 2.8% and 24.5%). The use of non-vitamin K antagonist oral anticoagulants (NOACs) increased more in DACH over time. Management of vitamin K antagonists was suboptimal in DACH and ORW (time in therapeutic range of INR ≥ 65% in 44.6% and 44.4% of patients or ≥ 70% in 36.9% and 36.0% of patients, respectively). Adjusted rates of cardiovascular mortality and MI/ACS were higher in DACH while non-haemorrhagic stroke/systemic embolism was lower after 2-year follow-up. Conclusions: Similarities and dissimilarities in AF management and clinical outcomes are seen in DACH and ORW. The increased use of NOAC was associated with a mismatch of risk-adapted anticoagulation (over-and-undertreatment) in DACH. Suboptimal control of INR requires educational activities in both regional groups. Higher rates of cardiovascular death in DACH may reflect the higher risk profile of these patients and lower rates of non-haemorrhagic stroke could be associated with increased NOAC use. Graphical abstract: [Figure not available: see fulltext.].

AB - Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is a worldwide non-interventional study of stroke prevention in patients with non-valvular AF. Methods and results: 52,080 patients with newly diagnosed AF were prospectively enrolled from 2010 to 2016. 4121 (7.9%) of these patients were recruited in DACH [Germany (n = 3567), Austria (n = 465) and Switzerland (n = 89) combined], and 47,959 patients were from 32 countries in other regions worldwide (ORW). Hypertension was most prevalent in DACH and ORW (85.3% and 75.6%, respectively). Diabetes, hypercholesterolaemia, carotid occlusive disease and vascular disease were more prevalent in DACH patients vs ORW (27.6%, 49.4%, 5.8% and 29.0% vs 21.7%, 40.9%, 2.8% and 24.5%). The use of non-vitamin K antagonist oral anticoagulants (NOACs) increased more in DACH over time. Management of vitamin K antagonists was suboptimal in DACH and ORW (time in therapeutic range of INR ≥ 65% in 44.6% and 44.4% of patients or ≥ 70% in 36.9% and 36.0% of patients, respectively). Adjusted rates of cardiovascular mortality and MI/ACS were higher in DACH while non-haemorrhagic stroke/systemic embolism was lower after 2-year follow-up. Conclusions: Similarities and dissimilarities in AF management and clinical outcomes are seen in DACH and ORW. The increased use of NOAC was associated with a mismatch of risk-adapted anticoagulation (over-and-undertreatment) in DACH. Suboptimal control of INR requires educational activities in both regional groups. Higher rates of cardiovascular death in DACH may reflect the higher risk profile of these patients and lower rates of non-haemorrhagic stroke could be associated with increased NOAC use. Graphical abstract: [Figure not available: see fulltext.].

KW - Atrial fibrillation

KW - GARFIELD-AF

KW - Non-vitamin K antagonist oral anticoagulants

KW - Oral anticoagulation

KW - Phenprocoumon

KW - Vitamin K antagonists

UR - http://www.scopus.com/inward/record.url?scp=85161036786&partnerID=8YFLogxK

U2 - 10.1007/s00392-022-02079-y

DO - 10.1007/s00392-022-02079-y

M3 - Article

C2 - 36094573

AN - SCOPUS:85161036786

SN - 1861-0684

VL - 112

SP - 759

EP - 771

JO - Clinical Research in Cardiology

JF - Clinical Research in Cardiology

IS - 6

ER -

the GARFIELD-AF Investigators, Haas S, Camm JA, Harald D, Steffel J, Virdone S et al. GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide. Clinical Research in Cardiology. 2023 Jun;112(6):759-771. doi: 10.1007/s00392-022-02079-y

GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide

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